biostudies-literatureMartin VMedical Research CouncilBiotechnology and Biological Sciences Research Council20140237https://www.ebi.ac.uk/biostudies/studies/S-EPMC4528414biostudies-literatureUnknown370(1676)Older people are more susceptible to infection, less responsive to vaccination and have a more inflammatory immune environment. Using spectratype analysis, we have previously shown that the B-cell repertoire of older people shows evidence of inappropriate clonal expansions in the absence of challenge, and that this loss of B-cell diversity correlates with poor health. Studies on response to vaccination, using both spectratyping and high-throughput sequencing of the repertoire, indicate that older responses to challenge are lacking in magnitude and/or delayed significantly. Also that some of the biologically significant differences may be in different classes of antibody. We have also previously shown that normal young B-cell repertoires can vary between different phenotypic subsets of B cePhilosophical transactions of the Royal Society of London. Series B, Biological sciencesAgeing of the B-cell repertoire.PMC4528414886421MR/L01257X/1BB/G017190/1Martin VKipling DDunn-Walters DBryan Wu YCfalseAgeing of the B-cell repertoire.Older people are more susceptible to infection, less responsive to vaccination and have a more inflammatory immune environment. Using spectratype analysis, we have previously shown that the B-cell repertoire of older people shows evidence of inappropriate clonal expansions in the absence of challenge, and that this loss of B-cell diversity correlates with poor health. Studies on response to vaccination, using both spectratyping and high-throughput sequencing of the repertoire, indicate that older responses to challenge are lacking in magnitude and/or delayed significantly. Also that some of the biologically significant differences may be in different classes of antibody. We have also previously shown that normal young B-cell repertoires can vary between different phenotypic subsets of B ce2015-01-01T00:00:00Z2015 Sep2025-04-04T21:25:28.796Z2019-03-26T22:39:15ZS-EPMC45284142619475110.1098/rstb.2014.0237