{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Liu H"],"pubmed_abstract":["<h4>Background</h4>Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polymorphisms and glioma risk.<h4>Methods</h4>We enrolled 300 glioma patients and 300 age- and gender-matched healthy controls. A prospective hospital-based case-control design and logistic regression analysis were utilized. The IL-8 gene polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).<h4>Results</h4>Glioma patients had a significantly higher frequency of IL-8 -251 AA genotype [odds ratio (OR) =1.91, 95% confid"],"journal":["Diagnostic pathology"],"pagination":["138"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4528780"],"repository":["biostudies-literature"],"pubmed_title":["Association between interleukin 8-251 T/A and +781 C/T polymorphisms and glioma risk."],"pmcid":["PMC4528780"],"pubmed_authors":["Liu H","Wang M","Mao P","Xie W","Jiang H","Xie C"],"additional_accession":[]},"is_claimable":false,"name":"Association between interleukin 8-251 T/A and +781 C/T polymorphisms and glioma risk.","description":"<h4>Background</h4>Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polymorphisms and glioma risk.<h4>Methods</h4>We enrolled 300 glioma patients and 300 age- and gender-matched healthy controls. A prospective hospital-based case-control design and logistic regression analysis were utilized. The IL-8 gene polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).<h4>Results</h4>Glioma patients had a significantly higher frequency of IL-8 -251 AA genotype [odds ratio (OR) =1.91, 95% confid","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Aug","modification":"2025-04-19T07:50:28.631Z","creation":"2019-03-27T01:56:27Z"},"accession":"S-EPMC4528780","cross_references":{"pubmed":["26249370"],"doi":["10.1186/s13000-015-0378-x"]}}