biostudies-literatureUnknown10Liu H<h4>Background</h4>Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polymorphisms and glioma risk.<h4>Methods</h4>We enrolled 300 glioma patients and 300 age- and gender-matched healthy controls. A prospective hospital-based case-control design and logistic regression analysis were utilized. The IL-8 gene polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).<h4>Results</h4>Glioma patients had a significantly higher frequency of IL-8 -251 AA genotype [odds ratio (OR) =1.91, 95% confidDiagnostic pathology138https://www.ebi.ac.uk/biostudies/studies/S-EPMC4528780biostudies-literatureAssociation between interleukin 8-251 T/A and +781 C/T polymorphisms and glioma risk.PMC4528780Liu HWang MMao PXie WJiang HXie CfalseAssociation between interleukin 8-251 T/A and +781 C/T polymorphisms and glioma risk.<h4>Background</h4>Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polymorphisms and glioma risk.<h4>Methods</h4>We enrolled 300 glioma patients and 300 age- and gender-matched healthy controls. A prospective hospital-based case-control design and logistic regression analysis were utilized. The IL-8 gene polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).<h4>Results</h4>Glioma patients had a significantly higher frequency of IL-8 -251 AA genotype [odds ratio (OR) =1.91, 95% confid2015-01-01T00:00:00Z2015 Aug2025-04-19T07:50:28.631Z2019-03-27T01:56:27ZS-EPMC45287802624937010.1186/s13000-015-0378-x