{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Ciccocioppo R"],"pubmed_abstract":["<h4>Introduction</h4>Crohn's disease (CD) is a disabling chronic enteropathy sustained by a harmful T-cell response toward antigens of the gut microbiota in genetically susceptible subjects. Growing evidence highlights the safety and possible efficacy of mesenchymal stem cells (MSCs) as a new therapeutic tool for this condition. Therefore, we aimed to investigate the effects of bone marrow-derived MSCs on pathogenic T cells with a view to clinical application.<h4>Methods</h4>T-cell lines from both inflamed and non-inflamed colonic mucosal specimens of CD patients and from healthy mucosa of control subjects were grown with the antigen muramyl-dipeptide in the absence or presence of donors' MSCs. The MSC effects were evaluated in terms of T-cell viability, apoptotic rate, proliferative respo"],"journal":["Stem cell research & therapy"],"pagination":["137"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4529692"],"repository":["biostudies-literature"],"pubmed_title":["Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn's disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact."],"pmcid":["PMC4529692"],"pubmed_authors":["Monti M","Cangemi GC","Kruzliak P","Martinetti M","Cervio M","Betti E","Gurrado A","Gobbi P","Bozzi V","Gallia A","Badulli C","Alvisi C","Visai L","Picone C","Ciccocioppo R","Pecci A","Dionigi P","Bernardo ME","Corazza GR"],"additional_accession":[]},"is_claimable":false,"name":"Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn's disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact.","description":"<h4>Introduction</h4>Crohn's disease (CD) is a disabling chronic enteropathy sustained by a harmful T-cell response toward antigens of the gut microbiota in genetically susceptible subjects. Growing evidence highlights the safety and possible efficacy of mesenchymal stem cells (MSCs) as a new therapeutic tool for this condition. Therefore, we aimed to investigate the effects of bone marrow-derived MSCs on pathogenic T cells with a view to clinical application.<h4>Methods</h4>T-cell lines from both inflamed and non-inflamed colonic mucosal specimens of CD patients and from healthy mucosa of control subjects were grown with the antigen muramyl-dipeptide in the absence or presence of donors' MSCs. The MSC effects were evaluated in terms of T-cell viability, apoptotic rate, proliferative respo","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2026-06-14T03:30:03.871Z","creation":"2019-06-06T14:43:25Z"},"accession":"S-EPMC4529692","cross_references":{"pubmed":["26206376"],"doi":["10.1186/s13287-015-0122-1"]}}