{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fredriksson L"],"funding":["The Swedish Governmental Agency for Innovation Systems","NIA NIH HHS","The Swedish Research Council","NHLBI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["722-38"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4531055"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(7)"],"pubmed_abstract":["<h4>Objective</h4>A growing body of evidence suggests that increased blood-brain barrier (BBB) permeability can contribute to the development of seizures. The protease tissue plasminogen activator (tPA) has been shown to promote BBB permeability and susceptibility to seizures. In this study, we examined the pathway regulated by tPA in seizures.<h4>Methods</h4>An experimental model of kainate-induced seizures was used in genetically modified mice, including mice deficient in tPA (tPA (-/-) ), its inhibitor neuroserpin (Nsp (-/-) ), or both (Nsp:tPA (-/-) ), and in mice conditionally deficient in the platelet-derived growth factor receptor alpha (PDGFRα).<h4>Results</h4>Compared to wild-type (WT) mice, Nsp (-/-) mice have significantly reduced latency to seizure onset and generalization; whe"],"journal":["Annals of clinical and translational neurology"],"pubmed_title":["Identification of a neurovascular signaling pathway regulating seizures in mice."],"pmcid":["PMC4531055"],"funding_grant_id":["P01 HL054710","T32 GM008322","2011-03503","2012-1853","T32 HL125242","R01 NS079639","R01 AG028488","R01 HL055374"],"pubmed_authors":["Su EJ","Ragsdale M","Moore S","Lawrence DA","Fredriksson L","Murphy GG","Craciun S","Stevenson TK","Schielke GP"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a neurovascular signaling pathway regulating seizures in mice.","description":"<h4>Objective</h4>A growing body of evidence suggests that increased blood-brain barrier (BBB) permeability can contribute to the development of seizures. The protease tissue plasminogen activator (tPA) has been shown to promote BBB permeability and susceptibility to seizures. In this study, we examined the pathway regulated by tPA in seizures.<h4>Methods</h4>An experimental model of kainate-induced seizures was used in genetically modified mice, including mice deficient in tPA (tPA (-/-) ), its inhibitor neuroserpin (Nsp (-/-) ), or both (Nsp:tPA (-/-) ), and in mice conditionally deficient in the platelet-derived growth factor receptor alpha (PDGFRα).<h4>Results</h4>Compared to wild-type (WT) mice, Nsp (-/-) mice have significantly reduced latency to seizure onset and generalization; whe","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2026-05-05T02:11:22.899Z","creation":"2019-03-27T01:56:33Z"},"accession":"S-EPMC4531055","cross_references":{"pubmed":["26273685"],"doi":["10.1002/acn3.209"]}}