{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(8)"],"submitter":["Putra AC"],"pubmed_abstract":["Hypoxia-inducible factor-2α (HIF-2α, or EPAS1) is important for cancer progression, and is a putative biomarker for poor prognosis for non-small cell lung cancer (NSCLC). However, molecular mechanisms underlying the EPAS1 overexpression are not still fully understood. We explored a role of a single nucleotide polymorphism (SNP), rs13419896 located within intron 1 of the EPAS1 gene in regulation of its expression. Bioinformatic analyses suggested that a region including the rs13419896 SNP plays a role in regulation of the EPAS1 gene expression and the SNP alters the binding activity of transcription factors. In vitro analyses demonstrated that a fragment containing the SNP locus function as a regulatory region and that a fragment with A allele showed higher transactivation activity than one"],"journal":["PloS one"],"pagination":["e0134496"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4532412"],"repository":["biostudies-literature"],"pubmed_title":["The A Allele at rs13419896 of EPAS1 Is Associated with Enhanced Expression and Poor Prognosis for Non-Small Cell Lung Cancer."],"pmcid":["PMC4532412"],"pubmed_authors":["Isobe T","Yamane Y","Eguchi H","Poellinger L","Putra AC","Gustine E","Tanimoto K","Nishiyama M","Lee KL","Hiyama K"],"additional_accession":[]},"is_claimable":false,"name":"The A Allele at rs13419896 of EPAS1 Is Associated with Enhanced Expression and Poor Prognosis for Non-Small Cell Lung Cancer.","description":"Hypoxia-inducible factor-2α (HIF-2α, or EPAS1) is important for cancer progression, and is a putative biomarker for poor prognosis for non-small cell lung cancer (NSCLC). However, molecular mechanisms underlying the EPAS1 overexpression are not still fully understood. We explored a role of a single nucleotide polymorphism (SNP), rs13419896 located within intron 1 of the EPAS1 gene in regulation of its expression. Bioinformatic analyses suggested that a region including the rs13419896 SNP plays a role in regulation of the EPAS1 gene expression and the SNP alters the binding activity of transcription factors. In vitro analyses demonstrated that a fragment containing the SNP locus function as a regulatory region and that a fragment with A allele showed higher transactivation activity than one","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-05-30T00:42:09.679Z","creation":"2019-03-26T23:35:20Z"},"accession":"S-EPMC4532412","cross_references":{"pubmed":["26263511"],"doi":["10.1371/journal.pone.0134496"]}}