biostudies-literatureHarrison SMedical Research CouncilWellcome Trust48https://www.ebi.ac.uk/biostudies/studies/S-EPMC4533938biostudies-literatureUnknown8<h4>Background</h4>The genetic basis of hearing loss in humans is relatively poorly understood. In recent years, experimental approaches including laboratory studies of early onset hearing loss in inbred mouse strains, or proteomic analyses of hair cells or hair bundles, have suggested new candidate molecules involved in hearing function. However, the relevance of these genes/gene products to hearing function in humans remains unknown. We investigated whether single nucleotide polymorphisms (SNPs) in the human orthologues of genes of interest arising from the above-mentioned studies correlate with hearing function in children.<h4>Methods</h4>577 SNPs from 13 genes were each analysed by linear regression against averaged high (3, 4 and 8 kHz) or low frequency (0.5, 1 and 2 kHz) audiometry dBMC medical genomicsAssociation of SNPs in LCP1 and CTIF with hearing in 11 year old children: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort and the G-EAR consortium.PMC4533938102215102215/2/13/2102432/Z/13/Z102432/Z/13/Z.MC_PC_15018Harrison SAdams JCLewis SJVuckovic DGirotto GHall AJMartin RMfalseAssociation of SNPs in LCP1 and CTIF with hearing in 11 year old children: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort and the G-EAR consortium.<h4>Background</h4>The genetic basis of hearing loss in humans is relatively poorly understood. In recent years, experimental approaches including laboratory studies of early onset hearing loss in inbred mouse strains, or proteomic analyses of hair cells or hair bundles, have suggested new candidate molecules involved in hearing function. However, the relevance of these genes/gene products to hearing function in humans remains unknown. We investigated whether single nucleotide polymorphisms (SNPs) in the human orthologues of genes of interest arising from the above-mentioned studies correlate with hearing function in children.<h4>Methods</h4>577 SNPs from 13 genes were each analysed by linear regression against averaged high (3, 4 and 8 kHz) or low frequency (0.5, 1 and 2 kHz) audiometry d2015-01-01T00:00:00Z2015 Aug2026-06-14T03:32:07.153Z2019-03-27T01:56:39ZS-EPMC45339382626404110.1186/s12920-015-0112-2