biostudies-literatureUnknown10(8)Ortiz MA<h4>Background</h4>Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Histocompatibility Complex. Additional risk loci with immunologically relevant genes were found significantly overrepresented. Nonetheless, it is accepted that most of the genetic architecture underlying susceptibility to the disease remains to be defined. Candidate association studies of the leukocyte immunoglobulin-like receptor LILRA3 gene in MS have been repeatedly reported with inconsistent results.<h4>Objectives</h4>In an attempt to shed some light on these controversial finPloS onee0134414https://www.ebi.ac.uk/biostudies/studies/S-EPMC4537248biostudies-literatureInfluence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis.PMC4537248Izquierdo GOrdonez DComabella MOrtiz MAArroyo RSanchez AJAlvarez-Cermeno JCUrcelay EVillar LMMartinez-Rodriguez JEMatesanz FNunez CGarcia-Merino AMontalban XMunteis EMalhotra SAlcina AfalseInfluence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis.<h4>Background</h4>Multiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Histocompatibility Complex. Additional risk loci with immunologically relevant genes were found significantly overrepresented. Nonetheless, it is accepted that most of the genetic architecture underlying susceptibility to the disease remains to be defined. Candidate association studies of the leukocyte immunoglobulin-like receptor LILRA3 gene in MS have been repeatedly reported with inconsistent results.<h4>Objectives</h4>In an attempt to shed some light on these controversial fin2015-01-01T00:00:00Z20152026-05-30T04:27:23.457Z2019-03-26T23:35:24ZS-EPMC45372482627482110.1371/journal.pone.0134414