biostudies-literatureLiu CNIEHS NIH HHSNHGRI NIH HHSNCI NIH HHS65https://www.ebi.ac.uk/biostudies/studies/S-EPMC4537530biostudies-literatureUnknown14<h4>Background</h4>Current studies of environmental health suggest a link between air pollution components, such as particulate matter (PM), and various diseases. However, the specific genes and regulatory mechanisms implicated in PM-induced diseases remain largely unknown. Epigenetic systems such as covalent modification of histones in chromatin may mediate environmental factors in gene regulation. Investigating the relationships between PM exposure and histone modification status may help understand the mechanisms underlying environment-associated health conditions.<h4>Methods</h4>In this study, we obtained genome-wide profiles of H3K27ac (histone 3 lysine 27 acetylation), known to be an active gene regulatory histone modification marker, in blood samples collected from four Chinese indiEnvironmental health : a global access science sourceCharacterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature.PMC4537530P30 ES000002P30 CA060553R21ES020010R21HG006367R21 ES020010P30CA060553R21 HG006367ES00002Zheng YZhu YGuo XDeng FXu JZhang WHou LNi YWang QChen YJoyce BTLiu CBaccarelli AfalseCharacterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature.<h4>Background</h4>Current studies of environmental health suggest a link between air pollution components, such as particulate matter (PM), and various diseases. However, the specific genes and regulatory mechanisms implicated in PM-induced diseases remain largely unknown. Epigenetic systems such as covalent modification of histones in chromatin may mediate environmental factors in gene regulation. Investigating the relationships between PM exposure and histone modification status may help understand the mechanisms underlying environment-associated health conditions.<h4>Methods</h4>In this study, we obtained genome-wide profiles of H3K27ac (histone 3 lysine 27 acetylation), known to be an active gene regulatory histone modification marker, in blood samples collected from four Chinese indi2015-01-01T00:00:00Z2015 Aug2026-06-15T06:42:24.627Z2019-03-27T01:56:49ZS-EPMC45375302627614610.1186/s12940-015-0052-5