{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Geserick P"],"pubmed_abstract":["Tumour progression and therapy resistance in squamous cell carcinoma of the skin (SCC) is strongly associated with resistance to intrinsic mitochondrial apoptosis. We thus investigated the role of various anti-apoptotic Bcl-2 proteins for apoptosis protection in SCC using the BH3 agonist ABT737 that can overcome multidomain Bcl-2 protein protection. Sensitive SCC cells underwent rapid loss of mitochondrial membrane potential (MMP), subsequent apoptosis concomitant with caspase-3 activation and an early release of mitochondria-derived cytochrome c and smac/DIABLO. In contrast, ABT737 resistance in subsets of SCC cells was not explained by XIAP, important for protection from DR-induced apoptosis in SCC. Of note, ABT737 did not prime SCC cells to DR-induced apoptosis. Interestingly, the ratio"],"journal":["Cell death & disease"],"pagination":["e1412"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4540197"],"repository":["biostudies-literature"],"pubmed_title":["The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin."],"pmcid":["PMC4540197"],"pubmed_authors":["Feoktistova M","Geserick P","Leverkus M","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin.","description":"Tumour progression and therapy resistance in squamous cell carcinoma of the skin (SCC) is strongly associated with resistance to intrinsic mitochondrial apoptosis. We thus investigated the role of various anti-apoptotic Bcl-2 proteins for apoptosis protection in SCC using the BH3 agonist ABT737 that can overcome multidomain Bcl-2 protein protection. Sensitive SCC cells underwent rapid loss of mitochondrial membrane potential (MMP), subsequent apoptosis concomitant with caspase-3 activation and an early release of mitochondria-derived cytochrome c and smac/DIABLO. In contrast, ABT737 resistance in subsets of SCC cells was not explained by XIAP, important for protection from DR-induced apoptosis in SCC. Of note, ABT737 did not prime SCC cells to DR-induced apoptosis. Interestingly, the ratio","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Sep","modification":"2025-04-05T12:13:24.997Z","creation":"2019-03-27T01:56:57Z"},"accession":"S-EPMC4540197","cross_references":{"pubmed":["25210795"],"doi":["10.1038/cddis.2014.379"]}}