{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Su Q"],"funding":["NCCIH NIH HHS","FIC NIH HHS"],"pagination":["1128-32"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4545407"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(12-13)"],"pubmed_abstract":["Bioassay-guided fractionation of an EtOH extract of the roots of the plant Apoplanesia paniculata (Fabaceae) led to the isolation of the three known compounds amorphaquinone (1), pendulone (2), and melilotocarpan C (3), and the two new pterocarpans 4 and 5. Compounds 1 and 2 exhibited good antiplasmodial activity with IC50 values of 5.7 ± 1.5 and 7.0 ± 0.8 µM, respectively. Compound 3 exhibited weak antiplasmodial activity (41.8 ± 5.2 µM), while compounds 4 and 5 were inactive. Compound 6 was synthesized to confirm the structure of 5, and it showed enhanced antiplasmodial activity (15.8 ± 1.4 µM) compared to its analogues 3-5."],"journal":["Planta medica"],"pubmed_title":["Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata."],"pmcid":["PMC4545407"],"funding_grant_id":["U01 TW000313-19","1 R01AT008088-01 3U01","TW000313-19S1","U01 TW000313","R01 AT008088"],"pubmed_authors":["Krai P","Kingston DG","Su Q","Cassera MB","Goetz M"],"additional_accession":[]},"is_claimable":false,"name":"Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata.","description":"Bioassay-guided fractionation of an EtOH extract of the roots of the plant Apoplanesia paniculata (Fabaceae) led to the isolation of the three known compounds amorphaquinone (1), pendulone (2), and melilotocarpan C (3), and the two new pterocarpans 4 and 5. Compounds 1 and 2 exhibited good antiplasmodial activity with IC50 values of 5.7 ± 1.5 and 7.0 ± 0.8 µM, respectively. Compound 3 exhibited weak antiplasmodial activity (41.8 ± 5.2 µM), while compounds 4 and 5 were inactive. Compound 6 was synthesized to confirm the structure of 5, and it showed enhanced antiplasmodial activity (15.8 ± 1.4 µM) compared to its analogues 3-5.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Aug","modification":"2025-06-01T02:37:58.955Z","creation":"2019-03-27T01:57:08Z"},"accession":"S-EPMC4545407","cross_references":{"pubmed":["26018916"],"doi":["10.1055/s-0035-1546036"]}}