biostudies-literatureSu QNCCIH NIH HHSFIC NIH HHS1128-32https://www.ebi.ac.uk/biostudies/studies/S-EPMC4545407biostudies-literatureUnknown81(12-13)Bioassay-guided fractionation of an EtOH extract of the roots of the plant Apoplanesia paniculata (Fabaceae) led to the isolation of the three known compounds amorphaquinone (1), pendulone (2), and melilotocarpan C (3), and the two new pterocarpans 4 and 5. Compounds 1 and 2 exhibited good antiplasmodial activity with IC50 values of 5.7 ± 1.5 and 7.0 ± 0.8 µM, respectively. Compound 3 exhibited weak antiplasmodial activity (41.8 ± 5.2 µM), while compounds 4 and 5 were inactive. Compound 6 was synthesized to confirm the structure of 5, and it showed enhanced antiplasmodial activity (15.8 ± 1.4 µM) compared to its analogues 3-5.Planta medicaAntiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata.PMC4545407U01 TW000313-191 R01AT008088-01 3U01TW000313-19S1U01 TW000313R01 AT008088Krai PKingston DGSu QCassera MBGoetz MfalseAntiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata.Bioassay-guided fractionation of an EtOH extract of the roots of the plant Apoplanesia paniculata (Fabaceae) led to the isolation of the three known compounds amorphaquinone (1), pendulone (2), and melilotocarpan C (3), and the two new pterocarpans 4 and 5. Compounds 1 and 2 exhibited good antiplasmodial activity with IC50 values of 5.7 ± 1.5 and 7.0 ± 0.8 µM, respectively. Compound 3 exhibited weak antiplasmodial activity (41.8 ± 5.2 µM), while compounds 4 and 5 were inactive. Compound 6 was synthesized to confirm the structure of 5, and it showed enhanced antiplasmodial activity (15.8 ± 1.4 µM) compared to its analogues 3-5.2015-01-01T00:00:00Z2015 Aug2025-06-01T02:37:58.955Z2019-03-27T01:57:08ZS-EPMC45454072601891610.1055/s-0035-1546036