{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(8)"],"submitter":["Traver S"],"pubmed_abstract":["Cell-free DNA (cfDNA) fragments, detected in blood and in other biological fluids, are released from apoptotic and/or necrotic cells. CfDNA is currently used as biomarker for the detection of many diseases such as some cancers and gynecological and obstetrics disorders. In this study, we investigated if cfDNA levels in follicular fluid (FF) samples from in vitro fertilization (IVF) patients, could be related to their ovarian reserve status, controlled ovarian stimulation (COS) protocols and IVF outcomes. Therefore, 117 FF samples were collected from women (n = 117) undergoing IVF/Intra-cytoplasmic sperm injection (ICSI) procedure and cfDNA concentration was quantified by ALU-quantitative PCR. We found that cfDNA level was significantly higher in FF samples from patients with ovarian reserv"],"journal":["PloS one"],"pagination":["e0136172"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4545729"],"repository":["biostudies-literature"],"pubmed_title":["Cell-free DNA in Human Follicular Microenvironment: New Prognostic Biomarker to Predict in vitro Fertilization Outcomes."],"pmcid":["PMC4545729"],"pubmed_authors":["Anahory T","Molinari N","Hamamah S","Scalici E","Mullet T","Vincens C","Traver S"],"additional_accession":[]},"is_claimable":false,"name":"Cell-free DNA in Human Follicular Microenvironment: New Prognostic Biomarker to Predict in vitro Fertilization Outcomes.","description":"Cell-free DNA (cfDNA) fragments, detected in blood and in other biological fluids, are released from apoptotic and/or necrotic cells. CfDNA is currently used as biomarker for the detection of many diseases such as some cancers and gynecological and obstetrics disorders. In this study, we investigated if cfDNA levels in follicular fluid (FF) samples from in vitro fertilization (IVF) patients, could be related to their ovarian reserve status, controlled ovarian stimulation (COS) protocols and IVF outcomes. Therefore, 117 FF samples were collected from women (n = 117) undergoing IVF/Intra-cytoplasmic sperm injection (ICSI) procedure and cfDNA concentration was quantified by ALU-quantitative PCR. We found that cfDNA level was significantly higher in FF samples from patients with ovarian reserv","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2025-04-04T12:39:03.175Z","creation":"2019-03-26T23:35:25Z"},"accession":"S-EPMC4545729","cross_references":{"pubmed":["26288130"],"doi":["10.1371/journal.pone.0136172"]}}