{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(8)"],"submitter":["Nocturne G"],"pubmed_abstract":["<h4>Objectives</h4>To investigate DKK-1 and SOST serum levels among patients with recent inflammatory back pain (IBP) fulfilling ASAS criteria for SpA and associated factors.<h4>Methods</h4>The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early IBP (duration >3 months and <3 years) suggestive of AxSpA. DKK-1 and SOST serum levels were assessed at baseline and were compared between the subgroup of patients fulfilling ASAS criteria for SpA (n = 486; 68.6%) and 80 healthy controls.<h4>Results</h4>Mean SOST serum levels were lower in ASAS+ patients than healthy controls (49.21 ± 25.9 vs. 87.8 ± 26 pmol/L; p<0.0001). In multivariate analysis, age (p = 5.4 10-9), CRP level (p<0.0001) and serum DKK-1 level (p = 0.001) were associated with SOST level. Mean DKK-1 se"],"journal":["PloS one"],"pagination":["e0134974"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4552086"],"repository":["biostudies-literature"],"pubmed_title":["Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort."],"pmcid":["PMC4552086"],"pubmed_authors":["Boudaoud S","Berenbaum F","Taylor KE","Roux C","Criswell LA","Dougados M","van der Heijde D","Mariette X","Seror R","van Gaalen F","Chanson P","Goupille P","Dieude P","Pavy S","Briot K","Feydy A","Nithitham J","Claudepierre P","Miceli-Richard C","Nocturne G"],"additional_accession":[]},"is_claimable":false,"name":"Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort.","description":"<h4>Objectives</h4>To investigate DKK-1 and SOST serum levels among patients with recent inflammatory back pain (IBP) fulfilling ASAS criteria for SpA and associated factors.<h4>Methods</h4>The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early IBP (duration >3 months and <3 years) suggestive of AxSpA. DKK-1 and SOST serum levels were assessed at baseline and were compared between the subgroup of patients fulfilling ASAS criteria for SpA (n = 486; 68.6%) and 80 healthy controls.<h4>Results</h4>Mean SOST serum levels were lower in ASAS+ patients than healthy controls (49.21 ± 25.9 vs. 87.8 ± 26 pmol/L; p<0.0001). In multivariate analysis, age (p = 5.4 10-9), CRP level (p<0.0001) and serum DKK-1 level (p = 0.001) were associated with SOST level. Mean DKK-1 se","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-04-08T16:27:44.424Z","creation":"2019-03-26T23:35:31Z"},"accession":"S-EPMC4552086","cross_references":{"pubmed":["26313358"],"doi":["10.1371/journal.pone.0134974"]}}