biostudies-literatureUnknown10(8)Nocturne G<h4>Objectives</h4>To investigate DKK-1 and SOST serum levels among patients with recent inflammatory back pain (IBP) fulfilling ASAS criteria for SpA and associated factors.<h4>Methods</h4>The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early IBP (duration >3 months and <3 years) suggestive of AxSpA. DKK-1 and SOST serum levels were assessed at baseline and were compared between the subgroup of patients fulfilling ASAS criteria for SpA (n = 486; 68.6%) and 80 healthy controls.<h4>Results</h4>Mean SOST serum levels were lower in ASAS+ patients than healthy controls (49.21 ± 25.9 vs. 87.8 ± 26 pmol/L; p<0.0001). In multivariate analysis, age (p = 5.4 10-9), CRP level (p<0.0001) and serum DKK-1 level (p = 0.001) were associated with SOST level. Mean DKK-1 sePloS onee0134974https://www.ebi.ac.uk/biostudies/studies/S-EPMC4552086biostudies-literatureIncrease in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort.PMC4552086Boudaoud SBerenbaum FTaylor KERoux CCriswell LADougados Mvan der Heijde DMariette XSeror Rvan Gaalen FChanson PGoupille PDieude PPavy SBriot KFeydy ANithitham JClaudepierre PMiceli-Richard CNocturne GfalseIncrease in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort.<h4>Objectives</h4>To investigate DKK-1 and SOST serum levels among patients with recent inflammatory back pain (IBP) fulfilling ASAS criteria for SpA and associated factors.<h4>Methods</h4>The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early IBP (duration >3 months and <3 years) suggestive of AxSpA. DKK-1 and SOST serum levels were assessed at baseline and were compared between the subgroup of patients fulfilling ASAS criteria for SpA (n = 486; 68.6%) and 80 healthy controls.<h4>Results</h4>Mean SOST serum levels were lower in ASAS+ patients than healthy controls (49.21 ± 25.9 vs. 87.8 ± 26 pmol/L; p<0.0001). In multivariate analysis, age (p = 5.4 10-9), CRP level (p<0.0001) and serum DKK-1 level (p = 0.001) were associated with SOST level. Mean DKK-1 se2015-01-01T00:00:00Z20152026-04-08T16:27:44.424Z2019-03-26T23:35:31ZS-EPMC45520862631335810.1371/journal.pone.0134974