biostudies-literatureQuesenberry PJNCATS NIH HHSNIDDK NIH HHSNHLBI NIH HHSNCI NIH HHSNational Institutes of Health27575https://www.ebi.ac.uk/biostudies/studies/S-EPMC4553260biostudies-literatureUnknown4The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acidJournal of extracellular vesiclesPotential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.PMC4553260P50 CA095103T32 HL116249UH2 TR000880P30 DK058404UH3 TR000901U19 CA179514U19 CA179563UH3 TR000918UH3 TR000928R01 HL122547UH2 TR000901UH2 TR000928R01 CA163563UH2TR000875UH2 TR000875UH3 TR000880Danielson KBalaj LCoffey RJDas SZhang HGChen CCAliotta JWen SAbdel-Mageed ABChatterjee DQuesenberry PJTetta CFranklin JDooner MPusic ADSubramanya VPusic KMCamussi GGoldberg LGhiran IKraig RPfalsePotential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid2015-01-01T00:00:00Z20152025-04-26T21:55:27.886Z2019-03-27T01:57:30ZS-EPMC45532602632094210.3402/jev.v4.27575