{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Gupta CL"],"pubmed_abstract":["Emergence of the drug resistant variants of the Influenza A virus in the recent years has aroused a great need for the development of novel neuraminidase inhibitors for controlling the pandemic. The neuraminidase (NA) protein of the influenza virus has been the most potential target for the anti-influenza. However, in the absence of any experimental structure of the drug targeting NA protein of H1N1 influenza A virus as zanamivir and oseltamivir, the comprehensive study of the interaction of the drug molecules with the target protein has been missing. Hence in this study a computational 3-D structure of neuraminidase of H1N1 influenza A virus has been developed using homology modeling technique, and the same was validated for its reliability by ProSA web server in term of energy profile & "],"journal":["EXCLI journal"],"pagination":["215-25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4556016"],"repository":["biostudies-literature"],"pubmed_title":["Computational modeling and validation studies of 3-D structure of neuraminidase protein of H1N1 influenza A virus and subsequent in silico elucidation of piceid analogues as its potent inhibitors."],"pmcid":["PMC4556016"],"pubmed_authors":["Gupta CL","Akhtar S","Tiwari AK","Bajpaib P","Desai GS","Kandpal KN"],"additional_accession":[]},"is_claimable":false,"name":"Computational modeling and validation studies of 3-D structure of neuraminidase protein of H1N1 influenza A virus and subsequent in silico elucidation of piceid analogues as its potent inhibitors.","description":"Emergence of the drug resistant variants of the Influenza A virus in the recent years has aroused a great need for the development of novel neuraminidase inhibitors for controlling the pandemic. The neuraminidase (NA) protein of the influenza virus has been the most potential target for the anti-influenza. However, in the absence of any experimental structure of the drug targeting NA protein of H1N1 influenza A virus as zanamivir and oseltamivir, the comprehensive study of the interaction of the drug molecules with the target protein has been missing. Hence in this study a computational 3-D structure of neuraminidase of H1N1 influenza A virus has been developed using homology modeling technique, and the same was validated for its reliability by ProSA web server in term of energy profile & ","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2026-05-30T04:16:34.451Z","creation":"2019-03-27T01:57:36Z"},"accession":"S-EPMC4556016","cross_references":{"pubmed":["26417228"]}}