{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(3)"],"submitter":["Agarwal R"],"pubmed_abstract":["<h4>Background</h4>Leptin, a 16 kDa peptide hormone synthesized and secreted specifically from white adipose cells protects neurons against amyloid β-induced toxicity, by increasing Apolipoprotein E (APO E)-dependent uptake of β amyloid into the cells, thereby, protect individuals from developing Alzheimer's disease (AD). The APO E ε4 allele is a known genetic risk factor for AD by accelerating onset. It is estimated that the lifetime risk of developing AD increases to 29% for carriers with one ε4 allele and 9% for those with no ε4 allele.<h4>Objectives</h4>To determine the levels of serum leptin, cholesterol, low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) in the diagnosed cases of AD and the association of them with cognitive decline and Apolipoprotein E (APO E) gen"],"journal":["Annals of Indian Academy of Neurology"],"pagination":["320-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4564468"],"repository":["biostudies-literature"],"pubmed_title":["Effect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer's disease."],"pmcid":["PMC4564468"],"pubmed_authors":["Kushwaha SS","Agarwal R","Kukreti R","Tripathi CB","Talwar P"],"additional_accession":[]},"is_claimable":false,"name":"Effect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer's disease.","description":"<h4>Background</h4>Leptin, a 16 kDa peptide hormone synthesized and secreted specifically from white adipose cells protects neurons against amyloid β-induced toxicity, by increasing Apolipoprotein E (APO E)-dependent uptake of β amyloid into the cells, thereby, protect individuals from developing Alzheimer's disease (AD). The APO E ε4 allele is a known genetic risk factor for AD by accelerating onset. It is estimated that the lifetime risk of developing AD increases to 29% for carriers with one ε4 allele and 9% for those with no ε4 allele.<h4>Objectives</h4>To determine the levels of serum leptin, cholesterol, low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) in the diagnosed cases of AD and the association of them with cognitive decline and Apolipoprotein E (APO E) gen","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul-Sep","modification":"2025-04-18T17:02:33.63Z","creation":"2019-03-27T01:58:06Z"},"accession":"S-EPMC4564468","cross_references":{"pubmed":["26425011"],"doi":["10.4103/0972-2327.157255"]}}