biostudies-literatureUnknown18(3)Agarwal R<h4>Background</h4>Leptin, a 16 kDa peptide hormone synthesized and secreted specifically from white adipose cells protects neurons against amyloid β-induced toxicity, by increasing Apolipoprotein E (APO E)-dependent uptake of β amyloid into the cells, thereby, protect individuals from developing Alzheimer's disease (AD). The APO E ε4 allele is a known genetic risk factor for AD by accelerating onset. It is estimated that the lifetime risk of developing AD increases to 29% for carriers with one ε4 allele and 9% for those with no ε4 allele.<h4>Objectives</h4>To determine the levels of serum leptin, cholesterol, low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) in the diagnosed cases of AD and the association of them with cognitive decline and Apolipoprotein E (APO E) genAnnals of Indian Academy of Neurology320-6https://www.ebi.ac.uk/biostudies/studies/S-EPMC4564468biostudies-literatureEffect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer's disease.PMC4564468Kushwaha SSAgarwal RKukreti RTripathi CBTalwar PfalseEffect of apolipoprotein E (APO E) polymorphism on leptin in Alzheimer's disease.<h4>Background</h4>Leptin, a 16 kDa peptide hormone synthesized and secreted specifically from white adipose cells protects neurons against amyloid β-induced toxicity, by increasing Apolipoprotein E (APO E)-dependent uptake of β amyloid into the cells, thereby, protect individuals from developing Alzheimer's disease (AD). The APO E ε4 allele is a known genetic risk factor for AD by accelerating onset. It is estimated that the lifetime risk of developing AD increases to 29% for carriers with one ε4 allele and 9% for those with no ε4 allele.<h4>Objectives</h4>To determine the levels of serum leptin, cholesterol, low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C) in the diagnosed cases of AD and the association of them with cognitive decline and Apolipoprotein E (APO E) gen2015-01-01T00:00:00Z2015 Jul-Sep2025-04-18T17:02:33.63Z2019-03-27T01:58:06ZS-EPMC45644682642501110.4103/0972-2327.157255