{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xing Y"],"funding":["National Basic Research Program of China","Beijing Commission of Education","Beijing University of Agriculture","Hong Kong Research Grants Council","Natural Science Foundation of China Major Research Plan","Beijing Municipality"],"pagination":["5971-81"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4566985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["66(19)"],"pubmed_abstract":["Superoxide dismutases (SODs) are involved in plant adaptive responses to biotic and abiotic stresses but the upstream signalling process that modulates their expression is not clear. Expression of two iron SODs, FSD2 and FSD3, was significantly increased in Arabidopsis in response to NaCl treatment but blocked in transgenic MKK5-RNAi plant, mkk5. Using an assay system for transient expression in protoplasts, it was found that mitogen-activated protein kinase kinase 5 (MKK5) was also activated in response to salt stress. Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments, while mkk5 mutant exhibited hypersensitivity to salt stress in germination on salt-containing media. Moreover, another kinase, MPK6, was also involved in the MKK5-mediated iron superoxid"],"journal":["Journal of experimental botany"],"pubmed_title":["Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signalling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress."],"pmcid":["PMC4566985"],"funding_grant_id":["GZL2015006","AoE/M-05/12","IDHT20140509","473611","KZ20130020018","473512","91317307","2012CB114300","474313"],"pubmed_authors":["Zhang J","Xing Y","Chen WH","Jia W"],"additional_accession":[]},"is_claimable":false,"name":"Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signalling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress.","description":"Superoxide dismutases (SODs) are involved in plant adaptive responses to biotic and abiotic stresses but the upstream signalling process that modulates their expression is not clear. Expression of two iron SODs, FSD2 and FSD3, was significantly increased in Arabidopsis in response to NaCl treatment but blocked in transgenic MKK5-RNAi plant, mkk5. Using an assay system for transient expression in protoplasts, it was found that mitogen-activated protein kinase kinase 5 (MKK5) was also activated in response to salt stress. Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments, while mkk5 mutant exhibited hypersensitivity to salt stress in germination on salt-containing media. Moreover, another kinase, MPK6, was also involved in the MKK5-mediated iron superoxid","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2025-04-04T13:00:49.394Z","creation":"2022-02-10T15:47:27.658Z"},"accession":"S-EPMC4566985","cross_references":{"pubmed":["26136265"],"doi":["10.1093/jxb/erv305"]}}