{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Feng P"],"funding":["Chinese Academy of Sciences","National Natural Science Foundation of China"],"pagination":["11365-70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4568701"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["112(36)"],"pubmed_abstract":["Quinones are widely distributed in nature and exhibit diverse biological or pharmacological activities; however, their biosynthetic machineries are largely unknown. The bibenzoquinone oosporein was first identified from the ascomycete insect pathogen Beauveria bassiana>50 y ago. The toxin can also be produced by different plant pathogenic and endophytic fungi with an array of biological activities. Here, we report the oosporein biosynthetic machinery in fungi, a polyketide synthase (PKS) pathway including seven genes for quinone biosynthesis. The PKS oosporein synthase 1 (OpS1) produces orsellinic acid that is hydroxylated to benzenetriol by the hydroxylase OpS4. The intermediate is oxidized either nonenzymatically to 5,5'-dideoxy-oosporein or enzymatically to benzenetetrol by the putative"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Fungal biosynthesis of the bibenzoquinone oosporein to evade insect immunity."],"pmcid":["PMC4568701"],"funding_grant_id":["31225023","XDB11030100","KSZD-EW-Z-021-2-4"],"pubmed_authors":["Wang C","Cen K","Shang Y","Feng P"],"additional_accession":[]},"is_claimable":false,"name":"Fungal biosynthesis of the bibenzoquinone oosporein to evade insect immunity.","description":"Quinones are widely distributed in nature and exhibit diverse biological or pharmacological activities; however, their biosynthetic machineries are largely unknown. The bibenzoquinone oosporein was first identified from the ascomycete insect pathogen Beauveria bassiana>50 y ago. The toxin can also be produced by different plant pathogenic and endophytic fungi with an array of biological activities. Here, we report the oosporein biosynthetic machinery in fungi, a polyketide synthase (PKS) pathway including seven genes for quinone biosynthesis. The PKS oosporein synthase 1 (OpS1) produces orsellinic acid that is hydroxylated to benzenetriol by the hydroxylase OpS4. The intermediate is oxidized either nonenzymatically to 5,5'-dideoxy-oosporein or enzymatically to benzenetetrol by the putative","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2026-05-05T00:47:13.826Z","creation":"2019-03-27T01:58:18Z"},"accession":"S-EPMC4568701","cross_references":{"pubmed":["26305932"],"doi":["10.1073/pnas.1503200112"]}}