{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kamata T"],"funding":["Cancer Research UK"],"pagination":["1119-37"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4568947"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(9)"],"pubmed_abstract":["The tumour microenvironment is known to play an integral role in facilitating cancer progression at advanced stages, but its function in some pre-cancerous lesions remains elusive. We have used the (V600) (E)BRAF-driven mouse lung model that develop premalignant lesions to understand stroma-tumour interactions during pre-cancerous development. In this model, we have found that immature macrophage-lineage cells (IMCs) producing PDGFA, TGFβ and CC chemokines are recruited to the stroma of premalignant lung adenomas through CC chemokine receptor 1 (CCR1)-dependent mechanisms. Stromal IMCs promote proliferation and transcriptional alterations suggestive of epithelial-mesenchymal transition in isolated premalignant lung tumour cells ex vivo, and are required for the maintenance of early-stage l"],"journal":["EMBO molecular medicine"],"pubmed_title":["The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours."],"pmcid":["PMC4568947"],"funding_grant_id":["13083","C1362/A6969","C1362/A13083"],"pubmed_authors":["Jin H","Giblett S","Patel B","Pritchard C","Kamata T","Patel F","Foster C"],"additional_accession":[]},"is_claimable":false,"name":"The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours.","description":"The tumour microenvironment is known to play an integral role in facilitating cancer progression at advanced stages, but its function in some pre-cancerous lesions remains elusive. We have used the (V600) (E)BRAF-driven mouse lung model that develop premalignant lesions to understand stroma-tumour interactions during pre-cancerous development. In this model, we have found that immature macrophage-lineage cells (IMCs) producing PDGFA, TGFβ and CC chemokines are recruited to the stroma of premalignant lung adenomas through CC chemokine receptor 1 (CCR1)-dependent mechanisms. Stromal IMCs promote proliferation and transcriptional alterations suggestive of epithelial-mesenchymal transition in isolated premalignant lung tumour cells ex vivo, and are required for the maintenance of early-stage l","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2026-05-05T00:47:14.801Z","creation":"2019-03-27T01:58:20Z"},"accession":"S-EPMC4568947","cross_references":{"pubmed":["26183450"],"doi":["10.15252/emmm.201404838"]}}