{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Planas R"],"funding":["UZH","Swiss National Science Foundation","DFG Clinical Research Group","University of Zurich","German Ministry for Education and Research"],"pagination":["875-93"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4574806"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(9)"],"pubmed_abstract":["Objective
Multiple sclerosis (MS) is a disease of the central nervous system with marked heterogeneity in several aspects including pathological processes. Based on infiltrating immune cells, deposition of humoral factors and loss of oligodendrocytes and/or myelin proteins, four lesion patterns have been described. Pattern II is characterized by antibody and complement deposition in addition to T-cell infiltration. MS is considered a T-cell-mediated disease, but until now the study of pathogenic T cells has encountered major challenges, most importantly the limited access of brain-infiltrating T cells. Our objective was to identify, isolate, and characterize brain-infiltrating clonally expanded T cells in pattern II MS lesions.Methods
We used next-generation sequencing to i"],"journal":["Annals of clinical and translational neurology"],"pubmed_title":["Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions."],"pmcid":["PMC4574806"],"funding_grant_id":["KFO 228/1","146945","SNF: 310030_146945","FK-13-046","310030","SFB 841"],"pubmed_authors":["Heesen C","Ortiz Y","Salinas-Riester G","Bruck W","Sospedra M","Jelcic I","Vilarrasa N","Planas R","Metz I","Martin R"],"additional_accession":[]},"is_claimable":false,"name":"Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions.","description":"Objective
Multiple sclerosis (MS) is a disease of the central nervous system with marked heterogeneity in several aspects including pathological processes. Based on infiltrating immune cells, deposition of humoral factors and loss of oligodendrocytes and/or myelin proteins, four lesion patterns have been described. Pattern II is characterized by antibody and complement deposition in addition to T-cell infiltration. MS is considered a T-cell-mediated disease, but until now the study of pathogenic T cells has encountered major challenges, most importantly the limited access of brain-infiltrating T cells. Our objective was to identify, isolate, and characterize brain-infiltrating clonally expanded T cells in pattern II MS lesions.Methods
We used next-generation sequencing to i","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2026-05-03T06:55:01.465Z","creation":"2019-03-27T01:58:38Z"},"accession":"S-EPMC4574806","cross_references":{"pubmed":["26401510"],"doi":["10.1002/acn3.218"]}}