{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Vettore AL"],"funding":["National Cancer Centre Research Foundation","Singhealth Foundation","Cancer Science Intitute","National Medical Research Council","National University Health System","Duke-NUS"],"pubmed_abstract":["<h4>Background</h4>Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival. The last three decades has witnessed a change in the OTSCC epidemiological profile, with increasing incidence in younger patients, females and never-smokers. Here, we sought to characterize the OTSCC genomic landscape and to determine factors that may delineate the genetic basis of this disease, inform prognosis and identify targets for therapeutic intervention.<h4>Methods</h4>Seventy-eight cases were subjected to whole-exome (n = 18) and targeted deep sequencing (n = 60).<h4>Results</h4>While the most common mutation was in TP53, the OTSCC genetic landscape differed from previously described cohorts of patients with head and neck"],"journal":["Genome medicine"],"pagination":["98"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4580363"],"repository":["biostudies-literature"],"pubmed_title":["Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance."],"pmcid":["PMC4580363"],"pubmed_authors":["Cutcutache I","Huang KK","Mcpherson JR","Poore G","Leong HS","Ong CK","Zhang S","Lim TK","Teh BT","Lim WK","Tan DS","Ramnarayanan K","Chong FT","Skanthakumar T","Cho BC","Rozen S","Suzuki Y","Iyer NG","Wang W","Lim K","Tan P","Vettore AL"],"additional_accession":[]},"is_claimable":false,"name":"Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.","description":"<h4>Background</h4>Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival. The last three decades has witnessed a change in the OTSCC epidemiological profile, with increasing incidence in younger patients, females and never-smokers. Here, we sought to characterize the OTSCC genomic landscape and to determine factors that may delineate the genetic basis of this disease, inform prognosis and identify targets for therapeutic intervention.<h4>Methods</h4>Seventy-eight cases were subjected to whole-exome (n = 18) and targeted deep sequencing (n = 60).<h4>Results</h4>While the most common mutation was in TP53, the OTSCC genetic landscape differed from previously described cohorts of patients with head and neck","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2026-06-06T22:47:43.235Z","creation":"2021-02-21T02:29:59Z"},"accession":"S-EPMC4580363","cross_references":{"pubmed":["26395002"],"doi":["10.1186/s13073-015-0219-2"]}}