biostudies-literatureUnknown7Vettore ALNational Cancer Centre Research FoundationSinghealth FoundationCancer Science IntituteNational Medical Research CouncilNational University Health SystemDuke-NUS<h4>Background</h4>Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival. The last three decades has witnessed a change in the OTSCC epidemiological profile, with increasing incidence in younger patients, females and never-smokers. Here, we sought to characterize the OTSCC genomic landscape and to determine factors that may delineate the genetic basis of this disease, inform prognosis and identify targets for therapeutic intervention.<h4>Methods</h4>Seventy-eight cases were subjected to whole-exome (n = 18) and targeted deep sequencing (n = 60).<h4>Results</h4>While the most common mutation was in TP53, the OTSCC genetic landscape differed from previously described cohorts of patients with head and neckGenome medicine98https://www.ebi.ac.uk/biostudies/studies/S-EPMC4580363biostudies-literatureMutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.PMC4580363Cutcutache IHuang KKMcpherson JRPoore GLeong HSOng CKZhang SLim TKTeh BTLim WKTan DSRamnarayanan KChong FTSkanthakumar TCho BCRozen SSuzuki YIyer NGWang WLim KTan PVettore ALfalseMutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.<h4>Background</h4>Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the oral cavity, characterized by frequent recurrence and poor survival. The last three decades has witnessed a change in the OTSCC epidemiological profile, with increasing incidence in younger patients, females and never-smokers. Here, we sought to characterize the OTSCC genomic landscape and to determine factors that may delineate the genetic basis of this disease, inform prognosis and identify targets for therapeutic intervention.<h4>Methods</h4>Seventy-eight cases were subjected to whole-exome (n = 18) and targeted deep sequencing (n = 60).<h4>Results</h4>While the most common mutation was in TP53, the OTSCC genetic landscape differed from previously described cohorts of patients with head and neck2015-01-01T00:00:00Z2015 Sep2026-06-06T22:47:43.235Z2021-02-21T02:29:59ZS-EPMC45803632639500210.1186/s13073-015-0219-2