{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Blasi A"],"funding":["Economic and Social Research Council","Simons Foundation","Medical Research Council","European Union's Seventh Framework Programme","National Institute for Health Research (NIHR)","Autistica","Innovative Medicines Initiative Joint","EFPIA"],"pagination":["122-33"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4582069"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["71"],"pubmed_abstract":["Adults diagnosed with autism spectrum disorder (ASD) show a reduced sensitivity (degree of selective response) to social stimuli such as human voices. In order to determine whether this reduced sensitivity is a consequence of years of poor social interaction and communication or is present prior to significant experience, we used functional MRI to examine cortical sensitivity to auditory stimuli in infants at high familial risk for later emerging ASD (HR group, N = 15), and compared this to infants with no family history of ASD (LR group, N = 18). The infants (aged between 4 and 7 months) were presented with voice and environmental sounds while asleep in the scanner and their behaviour was also examined in the context of observed parent-infant interaction. Whereas LR infants showed early s"],"journal":["Cortex; a journal devoted to the study of the nervous system and behavior"],"pubmed_title":["Atypical processing of voice sounds in infants at risk for autism spectrum disorder."],"pmcid":["PMC4582069"],"funding_grant_id":["ES/K001329/1","7221","SFARI201287","G0400061","RP-PG-0606-1045","G0701484","115300","MR/K021389/1","FP7/2007–2013","ES/G017603/1"],"pubmed_authors":["Sethna V","Murphy DG","Brammer MJ","Lloyd-Fox S","Mercure E","Murray L","Blasi A","Simmons A","Johnson MH","Williams SC"],"additional_accession":[]},"is_claimable":false,"name":"Atypical processing of voice sounds in infants at risk for autism spectrum disorder.","description":"Adults diagnosed with autism spectrum disorder (ASD) show a reduced sensitivity (degree of selective response) to social stimuli such as human voices. In order to determine whether this reduced sensitivity is a consequence of years of poor social interaction and communication or is present prior to significant experience, we used functional MRI to examine cortical sensitivity to auditory stimuli in infants at high familial risk for later emerging ASD (HR group, N = 15), and compared this to infants with no family history of ASD (LR group, N = 18). The infants (aged between 4 and 7 months) were presented with voice and environmental sounds while asleep in the scanner and their behaviour was also examined in the context of observed parent-infant interaction. Whereas LR infants showed early s","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Oct","modification":"2025-04-22T21:22:01.46Z","creation":"2019-03-27T01:58:56Z"},"accession":"S-EPMC4582069","cross_references":{"pubmed":["26200892"],"doi":["10.1016/j.cortex.2015.06.015"]}}