{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang X"],"funding":["NIA NIH HHS"],"pagination":["481-4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4582408"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["524(7566)"],"pubmed_abstract":["Mitochondria are multifunctional organelles whose dysfunction leads to neuromuscular degeneration and ageing. The multi-functionality poses a great challenge for understanding the mechanisms by which mitochondrial dysfunction causes specific pathologies. Among the leading mitochondrial mediators of cell death are energy depletion, free radical production, defects in iron-sulfur cluster biosynthesis, the release of pro-apoptotic and non-cell-autonomous signalling molecules, and altered stress signalling. Here we identify a new pathway of mitochondria-mediated cell death in yeast. This pathway was named mitochondrial precursor over-accumulation stress (mPOS), and is characterized by aberrant accumulation of mitochondrial precursors in the cytosol. mPOS can be triggered by clinically relevant"],"journal":["Nature"],"pubmed_title":["A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death."],"pmcid":["PMC4582408"],"funding_grant_id":["R21AG047400","R21 AG047400","R01 AG023731","R01AG023731"],"pubmed_authors":["Wang X","Chen XJ"],"additional_accession":[]},"is_claimable":false,"name":"A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death.","description":"Mitochondria are multifunctional organelles whose dysfunction leads to neuromuscular degeneration and ageing. The multi-functionality poses a great challenge for understanding the mechanisms by which mitochondrial dysfunction causes specific pathologies. Among the leading mitochondrial mediators of cell death are energy depletion, free radical production, defects in iron-sulfur cluster biosynthesis, the release of pro-apoptotic and non-cell-autonomous signalling molecules, and altered stress signalling. Here we identify a new pathway of mitochondria-mediated cell death in yeast. This pathway was named mitochondrial precursor over-accumulation stress (mPOS), and is characterized by aberrant accumulation of mitochondrial precursors in the cytosol. mPOS can be triggered by clinically relevant","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Aug","modification":"2025-04-05T12:25:21.576Z","creation":"2019-03-27T01:58:57Z"},"accession":"S-EPMC4582408","cross_references":{"pubmed":["26192197"],"doi":["10.1038/nature14859"]}}