biostudies-literatureWang XNIA NIH HHS481-4https://www.ebi.ac.uk/biostudies/studies/S-EPMC4582408biostudies-literatureUnknown524(7566)Mitochondria are multifunctional organelles whose dysfunction leads to neuromuscular degeneration and ageing. The multi-functionality poses a great challenge for understanding the mechanisms by which mitochondrial dysfunction causes specific pathologies. Among the leading mitochondrial mediators of cell death are energy depletion, free radical production, defects in iron-sulfur cluster biosynthesis, the release of pro-apoptotic and non-cell-autonomous signalling molecules, and altered stress signalling. Here we identify a new pathway of mitochondria-mediated cell death in yeast. This pathway was named mitochondrial precursor over-accumulation stress (mPOS), and is characterized by aberrant accumulation of mitochondrial precursors in the cytosol. mPOS can be triggered by clinically relevantNatureA cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death.PMC4582408R21AG047400R21 AG047400R01 AG023731R01AG023731Wang XChen XJfalseA cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death.Mitochondria are multifunctional organelles whose dysfunction leads to neuromuscular degeneration and ageing. The multi-functionality poses a great challenge for understanding the mechanisms by which mitochondrial dysfunction causes specific pathologies. Among the leading mitochondrial mediators of cell death are energy depletion, free radical production, defects in iron-sulfur cluster biosynthesis, the release of pro-apoptotic and non-cell-autonomous signalling molecules, and altered stress signalling. Here we identify a new pathway of mitochondria-mediated cell death in yeast. This pathway was named mitochondrial precursor over-accumulation stress (mPOS), and is characterized by aberrant accumulation of mitochondrial precursors in the cytosol. mPOS can be triggered by clinically relevant2015-01-01T00:00:00Z2015 Aug2025-04-05T12:25:21.576Z2019-03-27T01:58:57ZS-EPMC45824082619219710.1038/nature14859