{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vimaleswaran KS"],"funding":["Economic and Social Research Council","Intramural NIH HHS","British Heart Foundation","NIDDK NIH HHS","Medical Research Council","Chief Scientist Office","National Institute for Health Research (NIHR)","The British Heart Foundation funded the D-CarDia collaboration","Novo Nordisk Fonden","Wellcome Trust"],"pagination":["719-29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4582411"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(9)"],"pubmed_abstract":["<h4>Background</h4>Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.<h4>Methods</h4>In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We comple"],"journal":["The lancet. Diabetes & endocrinology"],"pubmed_title":["Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study."],"pmcid":["PMC4582411"],"funding_grant_id":["RG/08/008/25291","CZB/4/710","U1475000001","MC_U147585824","ES/K005146/1","NNF13OC0005785","RG/10/12/28456","ES/K005774/1","MC_UU_12011/4","ES/J023299/1","MC_UU_12011/1","NNF14OC0010513","R01 DK072041","MR/J012165/1","098381","MC_UP_A620_1014","MC_UP_A620_1017","MC_PC_U127592696","CZG/2/513","MC_UU_12019/1","MR/K013351/1","NF-SI-0508-10082","NF-SI-0513-10085","MR/K006584/1","G1001799","G0601653","PG/09/023/26806","MC_PC_U127561128","ES/H029745/1","PG/09/023"],"pubmed_authors":["McCarthy MI","Zgaga L","Florez JC","Hartman CA","Navis G","Fraser RM","Hagstrom E","Kleber ME","International Consortium for Blood Pressure (ICBP)","Berry DJ","Frayling TM","Price JF","Sorensen TI","Nolte IM","de Borst MH","Kritchevsky SB","Raitakari O","Lorentzon M","Brenner H","Hardy R","Karlsson M","Alves AC","Huffman JE","Salomaa V","Michaelsson K","Ripatti S","LifeLines Cohort Study investigators","Lohman KK","Paternoster L","Heerspink HJ","Houston DK","Global Blood Pressure Genetics (Global BPGen) consortium","Wong A","Herzig KH","Grimnes G","Cavadino A","Penninx BW","McLachlan S","Laitinen J","Rejnmark L","Jameson K","Tzoulaki I","Tikkanen E","Sebert S","Cooper JA","Mellstrom D","Whittaker JC","Dupuis J","Pouta A","Hernandez DG","Saum KU","Ohlsson C","Wilson JF","Wang TJ","Vimaleswaran KS","Kuh D","Spector TD","Jablonski KA","Ahluwalia TS","Lahti J","Thiering E","Langdahl BL","Ljunggren O","Pilz S","Wright AF","Lu C","Jula A","Eriksson JG","Jarvelin MR","Melhus H","Eriksson J","Marz W","van der Most PJ","Byberg L","Polasek O","Osmond C","Ingelsson E","Kivimaki M","de Boer RA","Acharya J","Jorde R","Stolk RP","Power C","Dieffenbach AK","Billings LK","Lind L","Bandinelli S","Mangino M","Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium","Lehtimaki T","van der Harst P","Rudan I","Arden N","Heinrich J","Tiesler CM","Vitart V","Snieder H","Navarro P","Hingorani AD","Campbell H","Pasko D","Caroline Hayward","Humphries SE","Schottker B","Theodoratou E","Cooper C","Hypponen E","Kumari M"],"additional_accession":[]},"is_claimable":false,"name":"Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.","description":"<h4>Background</h4>Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.<h4>Methods</h4>In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We comple","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Sep","modification":"2026-04-29T19:15:18.561Z","creation":"2019-03-27T01:58:57Z"},"accession":"S-EPMC4582411","cross_references":{"pubmed":["24974252"],"doi":["10.1016/S2213-8587(14)70113-5"]}}