biostudies-literatureVimaleswaran KSEconomic and Social Research CouncilIntramural NIH HHSBritish Heart FoundationNIDDK NIH HHSMedical Research CouncilChief Scientist OfficeNational Institute for Health Research (NIHR)The British Heart Foundation funded the D-CarDia collaborationNovo Nordisk FondenWellcome Trust719-29https://www.ebi.ac.uk/biostudies/studies/S-EPMC4582411biostudies-literatureUnknown2(9)<h4>Background</h4>Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.<h4>Methods</h4>In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We compleThe lancet. Diabetes & endocrinologyAssociation of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.PMC4582411RG/08/008/25291CZB/4/710U1475000001MC_U147585824ES/K005146/1NNF13OC0005785RG/10/12/28456ES/K005774/1MC_UU_12011/4ES/J023299/1MC_UU_12011/1NNF14OC0010513R01 DK072041MR/J012165/1098381MC_UP_A620_1014MC_UP_A620_1017MC_PC_U127592696CZG/2/513MC_UU_12019/1MR/K013351/1NF-SI-0508-10082NF-SI-0513-10085MR/K006584/1G1001799G0601653PG/09/023/26806MC_PC_U127561128ES/H029745/1PG/09/023McCarthy MIZgaga LFlorez JCHartman CANavis GFraser RMHagstrom EKleber MEInternational Consortium for Blood Pressure (ICBP)Berry DJFrayling TMPrice JFSorensen TINolte IMde Borst MHKritchevsky SBRaitakari OLorentzon MBrenner HHardy RKarlsson MAlves ACHuffman JESalomaa VMichaelsson KRipatti SLifeLines Cohort Study investigatorsLohman KKPaternoster LHeerspink HJHouston DKGlobal Blood Pressure Genetics (Global BPGen) consortiumWong AHerzig KHGrimnes GCavadino APenninx BWMcLachlan SLaitinen JRejnmark LJameson KTzoulaki ITikkanen ESebert SCooper JAMellstrom DWhittaker JCDupuis JPouta AHernandez DGSaum KUOhlsson CWilson JFWang TJVimaleswaran KSKuh DSpector TDJablonski KAAhluwalia TSLahti JThiering ELangdahl BLLjunggren OPilz SWright AFLu CJula AEriksson JGJarvelin MRMelhus HEriksson JMarz Wvan der Most PJByberg LPolasek OOsmond CIngelsson EKivimaki Mde Boer RAAcharya JJorde RStolk RPPower CDieffenbach AKBillings LKLind LBandinelli SMangino MCohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiumLehtimaki Tvan der Harst PRudan IArden NHeinrich JTiesler CMVitart VSnieder HNavarro PHingorani ADCampbell HPasko DCaroline HaywardHumphries SESchottker BTheodoratou ECooper CHypponen EKumari MfalseAssociation of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.<h4>Background</h4>Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.<h4>Methods</h4>In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We comple2014-01-01T00:00:00Z2014 Sep2026-04-29T19:15:18.561Z2019-03-27T01:58:57ZS-EPMC45824112497425210.1016/S2213-8587(14)70113-5