{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu VW"],"funding":["Tosteson & Fund for Medical Discovery Fellowship","Proton Therapy Research and Treatment Center","NHLBI","MGH Federal Share","NHLBI NIH HHS","BD Biosciences","Bullock-Wellman Fellowship Award","NCI NIH HHS"],"pagination":["318-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4583650"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5"],"pubmed_abstract":["The bone marrow niche is recognized as a central player in maintaining and regulating the behavior of hematopoietic stem and progenitor cells. Specific gain-of and loss-of function experiments perturbing a range of osteolineage cells or their secreted proteins had been shown to affect stem cell maintenance (Calvi et al, 2003 [1]; Stier et al., 2005 [2]; Zhang et al., 2003 [3]; Nilsson et al., 2005 [4]; Greenbaum et al., 2013 [5]) and engraftment (Adam et al., 2006, 2009 [6,7]). We used specific in vivo cell deletion approaches to dissect the niche cell-parenchymal cell dependency in a complex bone marrow microenvironment. Endogenous deletion of osteocalcin-expressing (Ocn(+)) cells led to a loss of T immune cells (Yu et al., 2015 [8]. Ocn(+) cells express the Notch ligand DLL4 to communica"],"journal":["Genomics data"],"pubmed_title":["Transcriptome comparison of distinct osteolineage subsets in the hematopoietic stem cell niche using a triple fluorescent transgenic mouse model."],"pmcid":["PMC4583650"],"funding_grant_id":["U01 HL100402","R01 HL044851","HL044851","C06 CA059267","HL097794","R01 HL097794","HL100402"],"pubmed_authors":["Lymperi S","Scadden DT","Ferraro F","Yu VW"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome comparison of distinct osteolineage subsets in the hematopoietic stem cell niche using a triple fluorescent transgenic mouse model.","description":"The bone marrow niche is recognized as a central player in maintaining and regulating the behavior of hematopoietic stem and progenitor cells. Specific gain-of and loss-of function experiments perturbing a range of osteolineage cells or their secreted proteins had been shown to affect stem cell maintenance (Calvi et al, 2003 [1]; Stier et al., 2005 [2]; Zhang et al., 2003 [3]; Nilsson et al., 2005 [4]; Greenbaum et al., 2013 [5]) and engraftment (Adam et al., 2006, 2009 [6,7]). We used specific in vivo cell deletion approaches to dissect the niche cell-parenchymal cell dependency in a complex bone marrow microenvironment. Endogenous deletion of osteocalcin-expressing (Ocn(+)) cells led to a loss of T immune cells (Yu et al., 2015 [8]. Ocn(+) cells express the Notch ligand DLL4 to communica","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2025-04-22T14:18:14.966Z","creation":"2019-06-06T14:54:40Z"},"accession":"S-EPMC4583650","cross_references":{"pubmed":["26484277"],"doi":["10.1016/j.gdata.2015.06.001"]}}