biostudies-literatureGabehart KNational Institute of Environmental Health SciencesNICHD NIH HHSNIEHS NIH HHSNational Institute of Child Health and Human Development117https://www.ebi.ac.uk/biostudies/studies/S-EPMC4583721biostudies-literatureUnknown16<h4>Background</h4>Ozone pollution has adverse effects on respiratory health in children and adults. This study was carried out in the mouse model to investigate the influence of age and to define the role of toll-like receptor four (TLR4) in the lung response to ozone exposure during postnatal development.<h4>Methods</h4>Female mice (1 to 6 weeks of age) were exposed for 3 h to ozone (1 part per million) or filtered air. Analyses were carried out at six and 24 h after completion of exposure, to assess the effects on lung permeability, airway neutrophilia, expression of antioxidants and chemokines, and mucus production. The role of TLR4 was defined by examining TLR4 expression in the lung during development, and by investigating the response to ozone in tlr4-deficient mice.<h4>Results</h4>Respiratory researchThe lung response to ozone is determined by age and is partially dependent on toll-Like receptor 4.PMC4583721P01 ES018181R01 HD053557Loader JEDakhama ACorrell KAWhite CWGabehart KfalseThe lung response to ozone is determined by age and is partially dependent on toll-Like receptor 4.<h4>Background</h4>Ozone pollution has adverse effects on respiratory health in children and adults. This study was carried out in the mouse model to investigate the influence of age and to define the role of toll-like receptor four (TLR4) in the lung response to ozone exposure during postnatal development.<h4>Methods</h4>Female mice (1 to 6 weeks of age) were exposed for 3 h to ozone (1 part per million) or filtered air. Analyses were carried out at six and 24 h after completion of exposure, to assess the effects on lung permeability, airway neutrophilia, expression of antioxidants and chemokines, and mucus production. The role of TLR4 was defined by examining TLR4 expression in the lung during development, and by investigating the response to ozone in tlr4-deficient mice.<h4>Results</h4>2015-01-01T00:00:00Z2015 Sep2026-06-10T08:50:47.339Z2019-06-06T14:54:43ZS-EPMC45837212641079210.1186/s12931-015-0279-2