biostudies-literatureHanssen EDutch Research Council (NWO)504https://www.ebi.ac.uk/biostudies/studies/S-EPMC4585217biostudies-literatureUnknown9Deficits in motivational behavior and psychotic symptoms often observed in schizophrenia (SZ) may be driven by dysfunctional reward processing (RP). RP can be divided in two different stages; reward anticipation and reward consumption. Aberrant processing during reward anticipation seems to be related to SZ. Studies in patients with SZ have found less activation in the ventral striatum (VS) during anticipation of reward, but these findings do not provide information on effect of the genetic load on reward processing. Therefore, this study investigated RP in healthy first-degree relatives of SZ patients. The sample consisted of 94 healthy siblings of SZ patients and 57 healthy controls. Participants completed a classic RP task, the Monetary Incentive Delay task, during functional magnetic rFrontiers in human neuroscienceNeural correlates of reward processing in healthy siblings of patients with schizophrenia.PMC4585217453-11-005453-11-004van der Velde JHanssen Evan Atteveldt NAleman Ade Haan LKrabbendam LGromann PMShergill SSBruggeman RfalseNeural correlates of reward processing in healthy siblings of patients with schizophrenia.Deficits in motivational behavior and psychotic symptoms often observed in schizophrenia (SZ) may be driven by dysfunctional reward processing (RP). RP can be divided in two different stages; reward anticipation and reward consumption. Aberrant processing during reward anticipation seems to be related to SZ. Studies in patients with SZ have found less activation in the ventral striatum (VS) during anticipation of reward, but these findings do not provide information on effect of the genetic load on reward processing. Therefore, this study investigated RP in healthy first-degree relatives of SZ patients. The sample consisted of 94 healthy siblings of SZ patients and 57 healthy controls. Participants completed a classic RP task, the Monetary Incentive Delay task, during functional magnetic r2015-01-01T00:00:00Z20152025-04-21T20:26:27.02Z2019-03-27T01:59:03ZS-EPMC45852172644160110.3389/fnhum.2015.00504