{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Huang D"],"pubmed_abstract":["Autophagy plays a key role in human health and disease, especially in cancer and neurodegeneration. Many autophagy regulators are developed for therapy. Diverse nanomaterials have been reported to induce autophagy. However, the underlying mechanisms and universal rules remain unclear. Here, for the first time, we show a reliable and general mechanism by which nanoparticles induce autophagy and then successfully modulate autophagy via tuning their dispersity. Various well-designed univariate experiments demonstrate that nanomaterials induce autophagy in a dispersity-dependent manner. Aggregated nanoparticles induce significant autophagic effect in comparison with well-dispersed nanoparticles. As the highly stable nanoparticles may block autophagic degradation in autolysosomes, endocytosis a"],"journal":["Scientific reports"],"pagination":["14361"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4585824"],"repository":["biostudies-literature"],"pubmed_title":["Nanoparticles modulate autophagic effect in a dispersity-dependent manner."],"pmcid":["PMC4585824"],"pubmed_authors":["Huang D","Gao J","Zhou H"],"additional_accession":[]},"is_claimable":false,"name":"Nanoparticles modulate autophagic effect in a dispersity-dependent manner.","description":"Autophagy plays a key role in human health and disease, especially in cancer and neurodegeneration. Many autophagy regulators are developed for therapy. Diverse nanomaterials have been reported to induce autophagy. However, the underlying mechanisms and universal rules remain unclear. Here, for the first time, we show a reliable and general mechanism by which nanoparticles induce autophagy and then successfully modulate autophagy via tuning their dispersity. Various well-designed univariate experiments demonstrate that nanomaterials induce autophagy in a dispersity-dependent manner. Aggregated nanoparticles induce significant autophagic effect in comparison with well-dispersed nanoparticles. As the highly stable nanoparticles may block autophagic degradation in autolysosomes, endocytosis a","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2025-04-21T20:21:33.814Z","creation":"2019-03-27T01:59:07Z"},"accession":"S-EPMC4585824","cross_references":{"pubmed":["26394839"],"doi":["10.1038/srep14361"]}}