biostudies-literatureTyler CRNational Institute of Environmental Health SciencesNIEHS NIH HHSPilot Project Award from the UNM HSC Environmental Health Signature ProgramNational Institute of Mental Health248-54https://www.ebi.ac.uk/biostudies/studies/S-EPMC4589800biostudies-literatureUnknown5Exposure to the common environmental contaminant arsenic impacts the epigenetic landscape, including DNA methylation and histone modifications, of several cell types. Developmental arsenic exposure (DAE) increases acetylation and methylation of histone proteins and the protein expression of several chromatin-modifying enzymes in the dentate gyrus (DG) subregion of the adult male mouse brain [26]. To complement and support these data, ChIP-Seq analysis of DNA associated with trimethylation of histone 3 lysine 4 (H3K4me3) derived from the adult male DG after DAE was performed. DAE induced differential H3K4me3 enrichment on genes in pathways associated with cellular development and growth, cell death and survival, and neurological disorders, particularly as they relate to cancer, in the adultData in briefChIP-Seq analysis of the adult male mouse brain after developmental exposure to arsenic.PMC4589800R01 ES019583RO1ES019583F31 101984Tyler CRWeber JAEdwards JSAllan AMHessinger JMLabrecque MfalseChIP-Seq analysis of the adult male mouse brain after developmental exposure to arsenic.Exposure to the common environmental contaminant arsenic impacts the epigenetic landscape, including DNA methylation and histone modifications, of several cell types. Developmental arsenic exposure (DAE) increases acetylation and methylation of histone proteins and the protein expression of several chromatin-modifying enzymes in the dentate gyrus (DG) subregion of the adult male mouse brain [26]. To complement and support these data, ChIP-Seq analysis of DNA associated with trimethylation of histone 3 lysine 4 (H3K4me3) derived from the adult male DG after DAE was performed. DAE induced differential H3K4me3 enrichment on genes in pathways associated with cellular development and growth, cell death and survival, and neurological disorders, particularly as they relate to cancer, in the adult2015-01-01T00:00:00Z2015 Dec2026-04-08T09:49:59.38Z2019-03-27T01:59:20ZS-EPMC45898002654388810.1016/j.dib.2015.08.037