{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye AX"],"funding":["CIHR"],"pagination":["376-84"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4589841"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Many children born very preterm (≤32 weeks) experience significant cognitive difficulties, but the biological basis of such problems has not yet been determined. Functional MRI studies have implicated altered functional connectivity; however, little is known regarding the spatiotemporal organization of brain networks in this population. We provide the first examination of resting-state neuromagnetic connectivity mapped in brain space in school age children born very preterm. Thirty-four subjects (age range 7-12 years old), consisting of 17 very preterm-born children and 17 full-term born children were included. Very preterm-born children exhibited global decreases in inter-regional synchrony in all analysed frequency ranges, from theta (4-7 Hz) to high gamma (80-150 Hz; p < 0.01, corrected). These reductions were expressed in spatially and frequency specific brain networks (p < 0.0005, corrected). Our results demonstrate that mapping connectivity with high spatiotemporal resolution offers new insights into altered organization of neurophysiological networks which may contribute to the cognitive difficulties in this vulnerable population."],"journal":["NeuroImage. Clinical"],"pubmed_title":["Disconnected neuromagnetic networks in children born very preterm: Disconnected MEG networks in preterm children."],"pmcid":["PMC4589841"],"funding_grant_id":["MOP-136935","MOP-324530","MOP-119541"],"pubmed_authors":["AuCoin-Power M","Doesburg SM","Taylor MJ","Ye AX"],"additional_accession":[]},"is_claimable":false,"name":"Disconnected neuromagnetic networks in children born very preterm: Disconnected MEG networks in preterm children.","description":"Many children born very preterm (≤32 weeks) experience significant cognitive difficulties, but the biological basis of such problems has not yet been determined. Functional MRI studies have implicated altered functional connectivity; however, little is known regarding the spatiotemporal organization of brain networks in this population. We provide the first examination of resting-state neuromagnetic connectivity mapped in brain space in school age children born very preterm. Thirty-four subjects (age range 7-12 years old), consisting of 17 very preterm-born children and 17 full-term born children were included. Very preterm-born children exhibited global decreases in inter-regional synchrony in all analysed frequency ranges, from theta (4-7 Hz) to high gamma (80-150 Hz; p < 0.01, corrected). These reductions were expressed in spatially and frequency specific brain networks (p < 0.0005, corrected). Our results demonstrate that mapping connectivity with high spatiotemporal resolution offers new insights into altered organization of neurophysiological networks which may contribute to the cognitive difficulties in this vulnerable population.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-19T06:26:38.115Z","creation":"2019-03-27T01:59:19Z"},"accession":"S-EPMC4589841","cross_references":{"pubmed":["27330980"],"doi":["10.1016/j.nicl.2015.08.016"]}}