{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["282(1810)"],"submitter":["Aiello BR"],"pubmed_abstract":["Hypotheses suggest that structural integrity of vertebrate bones is maintained by controlling bone strain magnitude via adaptive modelling in response to mechanical stimuli. Increased tissue-level strain magnitude and rate have both been identified as potent stimuli leading to increased bone formation. Mechanotransduction models hypothesize that osteocytes sense bone deformation by detecting fluid flow-induced drag in the bone's lacunar-canalicular porosity. This model suggests that the osteocyte's intracellular response depends on fluid-flow rate, a product of bone strain rate and gradient, but does not provide a mechanism for detection of strain magnitude. Such a mechanism is necessary for bone modelling to adapt to loads, because strain magnitude is an important determinant of skeletal "],"journal":["Proceedings. Biological sciences"],"pagination":["20150321"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4590470"],"repository":["biostudies-literature"],"pubmed_title":["Bone strain magnitude is correlated with bone strain rate in tetrapods: implications for models of mechanotransduction."],"pmcid":["PMC4590470"],"pubmed_authors":["Iriarte-Diaz J","Ross CF","Main RP","Butcher MT","Blob RW","Carrano MT","Espinoza NR","Aiello BR"],"additional_accession":[]},"is_claimable":false,"name":"Bone strain magnitude is correlated with bone strain rate in tetrapods: implications for models of mechanotransduction.","description":"Hypotheses suggest that structural integrity of vertebrate bones is maintained by controlling bone strain magnitude via adaptive modelling in response to mechanical stimuli. Increased tissue-level strain magnitude and rate have both been identified as potent stimuli leading to increased bone formation. Mechanotransduction models hypothesize that osteocytes sense bone deformation by detecting fluid flow-induced drag in the bone's lacunar-canalicular porosity. This model suggests that the osteocyte's intracellular response depends on fluid-flow rate, a product of bone strain rate and gradient, but does not provide a mechanism for detection of strain magnitude. Such a mechanism is necessary for bone modelling to adapt to loads, because strain magnitude is an important determinant of skeletal ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jul","modification":"2025-04-19T06:24:46.81Z","creation":"2019-03-26T22:40:19Z"},"accession":"S-EPMC4590470","cross_references":{"pubmed":["26063842"],"doi":["10.1098/rspb.2015.0321"]}}