biostudies-literatureUnknown282(1810)Aiello BRHypotheses suggest that structural integrity of vertebrate bones is maintained by controlling bone strain magnitude via adaptive modelling in response to mechanical stimuli. Increased tissue-level strain magnitude and rate have both been identified as potent stimuli leading to increased bone formation. Mechanotransduction models hypothesize that osteocytes sense bone deformation by detecting fluid flow-induced drag in the bone's lacunar-canalicular porosity. This model suggests that the osteocyte's intracellular response depends on fluid-flow rate, a product of bone strain rate and gradient, but does not provide a mechanism for detection of strain magnitude. Such a mechanism is necessary for bone modelling to adapt to loads, because strain magnitude is an important determinant of skeletal Proceedings. Biological sciences20150321https://www.ebi.ac.uk/biostudies/studies/S-EPMC4590470biostudies-literatureBone strain magnitude is correlated with bone strain rate in tetrapods: implications for models of mechanotransduction.PMC4590470Iriarte-Diaz JRoss CFMain RPButcher MTBlob RWCarrano MTEspinoza NRAiello BRfalseBone strain magnitude is correlated with bone strain rate in tetrapods: implications for models of mechanotransduction.Hypotheses suggest that structural integrity of vertebrate bones is maintained by controlling bone strain magnitude via adaptive modelling in response to mechanical stimuli. Increased tissue-level strain magnitude and rate have both been identified as potent stimuli leading to increased bone formation. Mechanotransduction models hypothesize that osteocytes sense bone deformation by detecting fluid flow-induced drag in the bone's lacunar-canalicular porosity. This model suggests that the osteocyte's intracellular response depends on fluid-flow rate, a product of bone strain rate and gradient, but does not provide a mechanism for detection of strain magnitude. Such a mechanism is necessary for bone modelling to adapt to loads, because strain magnitude is an important determinant of skeletal 2015-01-01T00:00:00Z2015 Jul2025-04-19T06:24:46.81Z2019-03-26T22:40:19ZS-EPMC45904702606384210.1098/rspb.2015.0321