{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Winkler TW"],"funding":["NICHD NIH HHS","Cancer Research UK","NCATS NIH HHS","Versus Arthritis","NIA NIH HHS","NHLBI NIH HHS","NIMH NIH HHS","NIAAA NIH HHS","European Research Council","Dutch Research Council (NWO)","National Institute for Health Research (NIHR)","NINDS NIH HHS","NIAMS NIH HHS","Novo Nordisk Fonden","Intramural NIH HHS","British Heart Foundation","NIDA NIH HHS","NCRR NIH HHS","NNF Center for Basic Metabolic Research","ZonMw","Lundbeck Foundation","Swiss National Science Foundation","NIDDK NIH HHS","Medical Research Council","NIMHD NIH HHS","NHGRI NIH HHS","Chief Scientist Office","NCI NIH HHS","Wellcome Trust","NIGMS NIH HHS"],"pagination":["e1005378"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4591371"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(10)"],"pubmed_abstract":["Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were com"],"journal":["PLoS genetics"],"pubmed_title":["The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study."],"pmcid":["PMC4591371"],"funding_grant_id":["U01 NS069208","U01 HG004423","U01 HL084756","RC2 MH089951","047.017.043","U01 CA098233","079895","076113/B/04/Z","MR/K002414/1","R01 MH061675","R01 DA012854","NNF12OC1016167","R01 MH067257","M01 RR016500","R01 AG023629","P30 DK072488","UL1 RR025005","R01 HL045670","T32 HL007055","N01 HG065403","U01 MH079470","R01 AA007535","R01 MH060879","R01 AG030146","U01 HG004438","294713","U01 HG004436","UL1 TR000124","R01 HL120393","NF-SI-0512-10114","U01 GM074518","HHSN268200800007C","20109","R01 DK075787","N01 HC055222","R01 HL036310","R01 MD009164","U01 MH079469","R01 NS045012","R01 MH060870","R01 HL117078","G1001799","P60 AR049465","P30 DK063491","MC_PC_U127561128","143914","U24 MH068457","NF-SI-0611-10219","91111025","R01 HL071981","CZB/4/710","U01 HG004402","UM1 CA182913","U01 DK062370","U01 HL080295","R37 AG013196","R01 AA013326","RP-PG-0407-10371","RG/10/12/28456","F32 AR059469","R01 MH059571","R01 DK093757","N01 HC025195","N01 HC055015","N01 HC055016","HHSN268200782096C","N01 HC055018","N01 HC055019","R01 AA013321","R01 AA013320","R01 HL080467","R01 CA047988","G1002319","064890","P60 AR030701","R01 HL087652","MR/N01104X/1","Z01 HG000024","084723/Z/08/Z","R01 DK075681","R01 MH059587","R01 MH059588","R01 MH059586","MC_U106179472","R01 AG010175","MC_U106179471","Kilpeläinen Group","P2C HD050924","G0600705","R01 HL087647","G0000934","R01 HG002651","RL1 MH083268","R01 DK062370","T32 AG000219","R01 HL103612","R01 AG017917","R01 HL105756","R01 HL087641","N01 AG012100","N01 HC085083","R01 DK091718","098017","N01 HC085082","R01 MH081800","N01 HC085081","RC2 MH089995","19542","R01 HL043851","N01 HC085086","Pers Group","NNF13OC0005785","N01 HC085080","R01 MH081802","R56 AG023629","NNF14OC0009883","R01 HL059367","R01 HL087679","P30 DK046200","T32 HL091823","P30 DK020572","NNF14OC0010513","NNF13OC0005781","T32 HG000040","098381","14136","R01 HL087676","R01 AG028555","R01 MH063706","Hansen Group","G1000143","R01 MH059565","R01 MH059566","MC_UP_A100_1003","P30 AG010161","N02 HL064278","20308","N01 HC055020","U01 HL105198","N01 HC055021","N01 HC055022","077016/Z/05/Z","RG/13/2/30098","NNF12OC1016374","RF1 AG015819","R01 DK089256","U01 DK062418","N01 AG012109","NNF14OC0011039","R01 DK072193","G0700931","R01 HL086694","068545","R01 AG015819","U01 HG004446","098395","R01 AG008724","NNF13OC0004839","18030","Grarup Group","MC_UU_12015/1","R01 AG013196","280559","086596/Z/08/Z","R190-2014-3904","U01 HL072515","G0601966","HHSN268201200036C","230374","NF-SI-0611-10099","U01 HL084729","NNF11OC1014855","R01 AG011101","MC_UU_12019/1","MC_UU_12015/5","MC_UU_12015/2","MR/K013351/1","R56 DA012854","P60 DK020541","NF-SI-0512-10135","P30 DK020541","G0401527","N01 HC085079","U54 RR020278","R01 AA014041"],"pubmed_authors":["Murray JC","Uitterlinden AG","Asselbergs FW","Berndt SI","Verweij N","Zhao JH","Kleber ME","Cadby G","Enroth S","Tonjes A","Bornstein SR","Walker M","Nolte IM","Kathiresan S","de Geus EJ","Milani L","Jalilzadeh S","Lehne B","Raitakari OT","Kaakinen M","Lanzani C","Broer L","McKnight B","McArdle WL","Scott RA","Thorsteinsdottir U","Kajantie E","Jackson AU","Yu L","Qi L","Heid IM","Huffman JE","Dueker N","Gordon-Larsen P","Fox CS","Tyrer JP","Khaw KT","Tsafantakis E","Bonnet F","Wong A","Smith AV","Banasik K","Stefania B","Luben R","Groop LC","Ridker PM","Dedoussis G","Bonnycastle LL","Hillege H","Volker U","Rivadeneira F","Kuusisto J","Kruger J","Rice TK","Johansson A","Cusi D","Barata L","Rose LM","Hingorani A","Koistinen HA","Sebert S","Mohlke KL","Perola M","Slagboom PE","Saltevo J","Wilson JF","Evans DA","Feenstra B","Kuh D","Tremoli E","Prokopenko I","Boehm BO","Syvanen AC","Hernandez D","de Groot LC","Heard-Costa NL","Gieger C","Kiemeney LA","Uusitupa M","Magi R","Jula A","Dimitriou M","Kahonen M","Shuldiner AR","Eriksson JG","Waite LL","Sarzynski MA","Andersson EA","Beilby J","Eriksson J","Smit JH","Muller G","Quertermous T","Rizzi F","Kinnunen L","Kivimaki M","Nieminen MS","Jaquish CE","Winkler TW","Lettre G","Illig T","Hysi PG","Scott WR","Liu Y","Lind L","Pasterkamp G","GLGC Consortium","Sennblad B","De Jager PL","Silveira A","Stringham HM","Montgomery GW","Pedersen O","Vermeulen SH","Mannisto S","Rueger S","Snieder H","Pervjakova N","Hansen T","Launer LJ","Montasser ME","Froguel P","Sinisalo J","Merger S","Leander K","Gottesman O","Volzke H","Scharnagl H","Hartman CA","Barlassina C","Sparso TH","Levinson DF","Chasman DI","Hengstenberg C","Gejman PV","Eury E","Delgado G","Tardif JC","Sung YJ","Melbye M","Tremblay A","Geller F","Gigante B","Perusse L","Bluher M","van Dijk SC","Ham AC","DIAGRAM Consortium","Staessen JA","Harris TB","Laakso M","Bergmann S","Panoutsopoulou K","Franke L","Jacobs KB","Blangero J","Graff M","Lotay V","Cole J","Albrecht E","Deloukas P","Rankinen T","Hofman A","Musk AW","Wareham NJ","Henders AK","Kanoni S","Mateo Leach I","Southam L","Vandenput L","Lo KS","Czajkowski J","Karaleftheri M","Haitjema S","Nelis M","Bennett DA","Grarup N","Pers TH","Jansen R","Rioux JD","Lyssenko V","Richards M","Wilsgaard T","Buchman AS","van der Velde N","Lindgren CM","Kittner SJ","de Bakker PI","Willenborg C","Schunkert H","Graßler J","Barroso I","Yerges-Armstrong LM","Waeber G","Gyllensten U","van Vliet-Ostaptchouk JV","Huikuri HV","Maerz W","Tuomilehto J","Mantyselka P","Wild SH","Chines PS","Kutalik Z","van der Most PJ","Ingelsson E","Vlachopoulou E","Mihailov E","de Craen AJ","Pramstaller PP","Ribel-Madsen R","Ryan KA","van der Harst P","Koskinen S","Galesloot TE","Kovacs P","Rudan I","Koenig W","Global-BPGen Consortium","Rao DC","Vitart V","Gronberg H","Chambers JC","Fall T","Kumari M","North KE","Cupples LA","Psaty BM","Narisu N","Martin NG","Jukema JW","Bottinger EP","Swertz MA","Luan J","Menni C","Liu YP","Stancakova A","Baldassarre D","Hassinen M","Njolstad I","Esko T","Holmen O","Loos RJ","Moll FL","Hui J","Justice AE","Watkins H","Lokki ML","Hall P","Hu F","Lorentzon M","Pankow JS","Tachmazidou I","Zeggini E","Collins FS","Boger CA","Alves AC","Waldenberger M","Seufferlein T","Vonk JM","Go AS","Eiriksdottir G","Vohl MC","Widen E","Cheng YC","Knekt PB","van Setten J","Kyriakou T","Chiang CW","Rayner NW","Bis JC","Boehnke M","Lannfelt L","Zillikens MC","Yengo L","Vollenweider P","Renstrom F","Boyd HA","Mitchell BD","Bakker SJ","Gorski M","Grallert H","Peters A","Rotter JI","Thorleifsson G","Pouta A","Sanna S","Absher D","Rivolta C","Ahluwalia TS","Lahti J","Chanock SJ","Willemsen G","Heath AC","van Duijn CM","James AL","Lagou V","Verbeek AL","Kilpelainen TO","Assimes TL","Muller-Nurasyid M","Ehret GB","de Faire U","Glorioso N","Kaplan RC","Benaglio P","Feitosa MF","Krarup NT","Hunter DJ","Westra HJ","Stolk RP","Rheinberger M","Mangino M","Morris AP","Hottenga JJ","Kooner JS","van Schoor NM","Metspalu A","Zhang W","Hirschhorn JN","Barcella M","Friedrich N","Thorand B","Bergman RN","Trompet S","McCarthy MI","Jordan JM","Kratzer W","Pilia MG","Chen YD","Gudnason V","Clegg DJ","Bruinenberg M","Palotie A","Mahajan A","White CC","Oldehinkel AJ","O'Connell JR","Cucca F","Hayward C","Bellis C","Chu S","Forouhi NG","Sorensen TI","Palmer LJ","Madden PA","van der Laan SW","Ong KK","Hattersley AT","Fischer K","Juonala M","Rauramaa R","Franks PW","Walker RW","Borecki IB","Erdmann J","Salomaa V","Lobbens S","Salo P","Wennauer R","Sattar N","Ferreira T","Paternoster L","Simino J","Tanaka T","Pedersen NL","Bouchard C","Pascoe L","Grammer TB","Goel A","Rice KM","Penninx BW","Karjalainen J","Boomsma DI","Eklund N","den Ruijter HM","Scholtens S","Teslovich TM","Demirkan A","Swift AJ","Boucher G","Gu YM","Beckmann JS","Teumer A","Shi J","Husemoen LL","Wang SR","Hicks AA","Lakka TA","Medina-Gomez C","Tan ST","Ford I","Schwarz PE","ICBP Consortium","Kolcic I","Stefansson K","Lu Y","Ahmad S","Claudi-Boehm S","Neinast MD","Monda KL","Boerwinkle E","Abecasis GR","Ohlsson C","Sanders AR","Hveem K","Bonnefond A","Stumvoll M","Ferrucci L","Spector TD","Gustafsson S","Bragg-Gresham JL","Strawbridge RJ","Wang Z","Oostra BA","Frau F","Yang J","Wright AF","Hutri-Kahonen N","CHARGE Consortium","Heliovaara M","Farrall M","Wallaschofski H","MAGIC Consortium","Hamsten A","Gansevoort RT","Linneberg A","Polasek O","Steinthorsdottir V","Farmaki AE","Schlessinger D","Viikari JS","Sengupta S","Duan J","Lehtimaki T","Chakravarti A","Pichler I","Hastie N","Strachan DP","Langenberg C","Magnusson PK","Campbell H","Jorgensen T","Hovingh KG","Stirrups K","Lindstrom J"],"additional_accession":[]},"is_claimable":false,"name":"The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.","description":"Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were com","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Oct","modification":"2026-04-29T22:19:13.514Z","creation":"2019-03-26T22:46:03Z"},"accession":"S-EPMC4591371","cross_references":{"pubmed":["26426971"],"doi":["10.1371/journal.pgen.1005378"]}}