biostudies-literatureWinkler TWNICHD NIH HHSCancer Research UKNCATS NIH HHSVersus ArthritisNIA NIH HHSNHLBI NIH HHSNIMH NIH HHSNIAAA NIH HHSEuropean Research CouncilDutch Research Council (NWO)National Institute for Health Research (NIHR)NINDS NIH HHSNIAMS NIH HHSNovo Nordisk FondenIntramural NIH HHSBritish Heart FoundationNIDA NIH HHSNCRR NIH HHSNNF Center for Basic Metabolic ResearchZonMwLundbeck FoundationSwiss National Science FoundationNIDDK NIH HHSMedical Research CouncilNIMHD NIH HHSNHGRI NIH HHSChief Scientist OfficeNCI NIH HHSWellcome TrustNIGMS NIH HHSe1005378https://www.ebi.ac.uk/biostudies/studies/S-EPMC4591371biostudies-literatureUnknown11(10)Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were comPLoS geneticsThe Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.PMC4591371U01 NS069208U01 HG004423U01 HL084756RC2 MH089951047.017.043U01 CA098233079895076113/B/04/ZMR/K002414/1R01 MH061675R01 DA012854NNF12OC1016167R01 MH067257M01 RR016500R01 AG023629P30 DK072488UL1 RR025005R01 HL045670T32 HL007055N01 HG065403U01 MH079470R01 AA007535R01 MH060879R01 AG030146U01 HG004438294713U01 HG004436UL1 TR000124R01 HL120393NF-SI-0512-10114U01 GM074518HHSN268200800007C20109R01 DK075787N01 HC055222R01 HL036310R01 MD009164U01 MH079469R01 NS045012R01 MH060870R01 HL117078G1001799P60 AR049465P30 DK063491MC_PC_U127561128143914U24 MH068457NF-SI-0611-1021991111025R01 HL071981CZB/4/710U01 HG004402UM1 CA182913U01 DK062370U01 HL080295R37 AG013196R01 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NFerreira TPaternoster LSimino JTanaka TPedersen NLBouchard CPascoe LGrammer TBGoel ARice KMPenninx BWKarjalainen JBoomsma DIEklund Nden Ruijter HMScholtens STeslovich TMDemirkan ASwift AJBoucher GGu YMBeckmann JSTeumer AShi JHusemoen LLWang SRHicks AALakka TAMedina-Gomez CTan STFord ISchwarz PEICBP ConsortiumKolcic IStefansson KLu YAhmad SClaudi-Boehm SNeinast MDMonda KLBoerwinkle EAbecasis GROhlsson CSanders ARHveem KBonnefond AStumvoll MFerrucci LSpector TDGustafsson SBragg-Gresham JLStrawbridge RJWang ZOostra BAFrau FYang JWright AFHutri-Kahonen NCHARGE ConsortiumHeliovaara MFarrall MWallaschofski HMAGIC ConsortiumHamsten AGansevoort RTLinneberg APolasek OSteinthorsdottir VFarmaki AESchlessinger DViikari JSSengupta SDuan JLehtimaki TChakravarti APichler IHastie NStrachan DPLangenberg CMagnusson PKCampbell HJorgensen THovingh KGStirrups KLindstrom JfalseThe Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were com2015-01-01T00:00:00Z2015 Oct2026-04-29T22:19:13.514Z2019-03-26T22:46:03ZS-EPMC45913712642697110.1371/journal.pgen.1005378