{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Othumpangat S"],"funding":["Intramural CDC HHS"],"pagination":["84-94"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4591961"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["447(1-2)"],"pubmed_abstract":["Understanding the host response to influenza A virus infection is essential for developing intervention approaches. We show that infection of human alveolar epithelial cells and human bronchial epithelial cells with influenza A for 3h resulted in down-regulation of host hsa-miRNA-548an (miRNA-548an) which triggered the overexpression of influenza non-structural-1A binding protein (IVNS1ABP, herein referred to as NS1ABP). Reduced NS1ABP mRNA and NS1ABP protein expression after transfection of miRNA-548an mimic or increased NS1ABP mRNA and NS1ABP protein expression after transfection of miRNA-548an inhibitor provided evidence that miRNA-548an is involved in the regulation of NS1ABP. Transfection of cells with inhibitor led to reduced apoptosis of infected cells while transfection of mimic le"],"journal":["Virology"],"pubmed_title":["Expression of non-structural-1A binding protein in lung epithelial cells is modulated by miRNA-548an on exposure to influenza A virus."],"pmcid":["PMC4591961"],"funding_grant_id":["CC999999"],"pubmed_authors":["Blachere FM","Othumpangat S","Noti JD","Beezhold DH"],"additional_accession":[]},"is_claimable":false,"name":"Expression of non-structural-1A binding protein in lung epithelial cells is modulated by miRNA-548an on exposure to influenza A virus.","description":"Understanding the host response to influenza A virus infection is essential for developing intervention approaches. We show that infection of human alveolar epithelial cells and human bronchial epithelial cells with influenza A for 3h resulted in down-regulation of host hsa-miRNA-548an (miRNA-548an) which triggered the overexpression of influenza non-structural-1A binding protein (IVNS1ABP, herein referred to as NS1ABP). Reduced NS1ABP mRNA and NS1ABP protein expression after transfection of miRNA-548an mimic or increased NS1ABP mRNA and NS1ABP protein expression after transfection of miRNA-548an inhibitor provided evidence that miRNA-548an is involved in the regulation of NS1ABP. Transfection of cells with inhibitor led to reduced apoptosis of infected cells while transfection of mimic le","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Dec","modification":"2025-04-20T00:33:45.066Z","creation":"2020-11-07T10:08:32Z"},"accession":"S-EPMC4591961","cross_references":{"pubmed":["24210102"],"doi":["10.1016/j.virol.2013.08.031"]}}