{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Borja-Tabora CF"],"pubmed_abstract":["<h4>Background</h4>Long-term protection against meningococcal disease is associated with persistence of post-vaccination antibodies at protective levels. We evaluated the bactericidal antibody persistence and safety of the quadrivalent meningococcal serogroups A, C, W and Y tetanus-toxoid conjugate vaccine (MenACWY-TT) and the meningococcal polysaccharide serogroups A, C, W, and Y vaccine (MenACWY-PS) up to 5 years post-vaccination.<h4>Methods</h4>This phase IIb, open, randomized, controlled study conducted in the Philippines and Saudi Arabia consisted of a vaccination phase and a long-term persistence phase. Healthy adolescents and adults aged 11-55 years were randomized (3:1) to receive a single dose of MenACWY-TT (ACWY-TT group) or MenACWY-PS (Men-PS group). Primary and persistence resu"],"journal":["BMC infectious diseases"],"pagination":["409"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4595195"],"repository":["biostudies-literature"],"pubmed_title":["Long-term immunogenicity and safety after a single dose of the quadrivalent meningococcal serogroups A, C, W, and Y tetanus toxoid conjugate vaccine in adolescents and adults: 5-year follow-up of an open, randomized trial."],"pmcid":["PMC4595195"],"pubmed_authors":["Borja-Tabora CF","Montalban C","Kolhe D","Van der Wielen M","Memish ZA","Miller JM","Boutriau D"],"additional_accession":[]},"is_claimable":false,"name":"Long-term immunogenicity and safety after a single dose of the quadrivalent meningococcal serogroups A, C, W, and Y tetanus toxoid conjugate vaccine in adolescents and adults: 5-year follow-up of an open, randomized trial.","description":"<h4>Background</h4>Long-term protection against meningococcal disease is associated with persistence of post-vaccination antibodies at protective levels. We evaluated the bactericidal antibody persistence and safety of the quadrivalent meningococcal serogroups A, C, W and Y tetanus-toxoid conjugate vaccine (MenACWY-TT) and the meningococcal polysaccharide serogroups A, C, W, and Y vaccine (MenACWY-PS) up to 5 years post-vaccination.<h4>Methods</h4>This phase IIb, open, randomized, controlled study conducted in the Philippines and Saudi Arabia consisted of a vaccination phase and a long-term persistence phase. Healthy adolescents and adults aged 11-55 years were randomized (3:1) to receive a single dose of MenACWY-TT (ACWY-TT group) or MenACWY-PS (Men-PS group). Primary and persistence resu","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Oct","modification":"2026-06-17T05:57:21.897Z","creation":"2019-03-27T01:59:35Z"},"accession":"S-EPMC4595195","cross_references":{"pubmed":["26437712"],"doi":["10.1186/s12879-015-1138-y"]}}