{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Omer H"],"pubmed_abstract":["Bacillus cereus is a Gram-positive pathogen that causes a wide variety of diseases in humans. It secretes into the extracellular milieu proteins that may contribute directly or indirectly to its virulence. EntD is a novel exoprotein identified by proteogenomics of B. cereus ATCC 14579. We constructed a ΔentD mutant and analyzed the impact of entD disruption on the cellular proteome and exoproteome isolated from early, late, and stationary-phase cultures. We identified 308 and 79 proteins regulated by EntD in the cellular proteome and the exoproteome, respectively. The contribution of these proteins to important virulence-associated functions, including central metabolism, cell structure, antioxidative ability, cell motility, and toxin production, are presented. The proteomic data were corr"],"journal":["Frontiers in microbiology"],"pagination":["1004"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4595770"],"repository":["biostudies-literature"],"pubmed_title":["Proteomics identifies Bacillus cereus EntD as a pivotal protein for the production of numerous virulence factors."],"pmcid":["PMC4595770"],"pubmed_authors":["Alpha-Bazin B","Armengaud J","Brunet JL","Duport C","Omer H"],"additional_accession":[]},"is_claimable":false,"name":"Proteomics identifies Bacillus cereus EntD as a pivotal protein for the production of numerous virulence factors.","description":"Bacillus cereus is a Gram-positive pathogen that causes a wide variety of diseases in humans. It secretes into the extracellular milieu proteins that may contribute directly or indirectly to its virulence. EntD is a novel exoprotein identified by proteogenomics of B. cereus ATCC 14579. We constructed a ΔentD mutant and analyzed the impact of entD disruption on the cellular proteome and exoproteome isolated from early, late, and stationary-phase cultures. We identified 308 and 79 proteins regulated by EntD in the cellular proteome and the exoproteome, respectively. The contribution of these proteins to important virulence-associated functions, including central metabolism, cell structure, antioxidative ability, cell motility, and toxin production, are presented. The proteomic data were corr","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-04-08T02:01:55.836Z","creation":"2019-03-27T01:59:38Z"},"accession":"S-EPMC4595770","cross_references":{"pubmed":["26500610"],"doi":["10.3389/fmicb.2015.01004"]}}