{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Urbanska K"],"funding":["NCI NIH HHS"],"pagination":["1130-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4596767"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(10)"],"pubmed_abstract":["Adoptive transfer of T cells engineered to express chimeric immunoreceptors is an effective strategy to treat hematologic cancers; however, the use of this type of therapy for solid cancers, such as ovarian cancer, remains challenging because a safe and effective immunotherapeutic target has not yet been identified. Here, we constructed and evaluated a novel redirected T-cell-based immunotherapy targeting human follicle-stimulating hormone receptor (FSHR), a highly conserved molecule in vertebrate animals with expression limited to gonadal tissues, ovarian cancer, and cancer-associated vasculature. Receptor ligand-based anti-FSHR immunoreceptors were constructed that contained small binding fragments from the ligand for FSHR, FSH, fused to T-cell transmembrane and T-cell signaling domains."],"journal":["Cancer immunology research"],"pubmed_title":["Follicle-Stimulating Hormone Receptor as a Target in the Redirected T-cell Therapy for Cancer."],"pmcid":["PMC4596767"],"funding_grant_id":["R01 CA168900","R01-CA168900"],"pubmed_authors":["Stashwick C","Urbanska K","Poussin M","Powell DJ"],"additional_accession":[]},"is_claimable":false,"name":"Follicle-Stimulating Hormone Receptor as a Target in the Redirected T-cell Therapy for Cancer.","description":"Adoptive transfer of T cells engineered to express chimeric immunoreceptors is an effective strategy to treat hematologic cancers; however, the use of this type of therapy for solid cancers, such as ovarian cancer, remains challenging because a safe and effective immunotherapeutic target has not yet been identified. Here, we constructed and evaluated a novel redirected T-cell-based immunotherapy targeting human follicle-stimulating hormone receptor (FSHR), a highly conserved molecule in vertebrate animals with expression limited to gonadal tissues, ovarian cancer, and cancer-associated vasculature. Receptor ligand-based anti-FSHR immunoreceptors were constructed that contained small binding fragments from the ligand for FSHR, FSH, fused to T-cell transmembrane and T-cell signaling domains.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Oct","modification":"2025-04-19T14:59:14.656Z","creation":"2019-03-27T01:59:40Z"},"accession":"S-EPMC4596767","cross_references":{"pubmed":["26112923"],"doi":["10.1158/2326-6066.cir-15-0047","10.1158/2326-6066.CIR-15-0047"]}}