biostudies-literatureUnknown10(10)Chen CH<h4>Aims</h4>Growth arrest-specific protein 6 (Gas6) is a vitamin K-dependent protein expressed by endothelial cells and leukocytes that are involved in cell survival, migration, and proliferation in response to inflammatory processes. The aim of this study was to assess the implications of Gas6 in Sjögren syndrome (SS) and its expression in the labial salivary gland.<h4>Methods and results</h4>A total of 254 adults, including 159 with primary Sjögren syndrome (pSS), 34 with secondary Sjögren syndrome (sSS), and 61 normal controls, were recruited. Plasma Gas6 concentrations were determined, and Gas6 expressions in labial salivary gland (LSG) tissues from controls and pSS and sSS patients were also evaluated. Plasma Gas6 concentrations were significantly lower among patients with pSS than nPloS onee0139955https://www.ebi.ac.uk/biostudies/studies/S-EPMC4596882biostudies-literatureGrowth Arrest-Specific 6 Protein in Patients with Sjogren Syndrome: Determination of the Plasma Level and Expression in the Labial Salivary Gland.PMC4596882Chang CCLee CHChen HCShieh YSLin YFPeng YJChen CHHung YJfalseGrowth Arrest-Specific 6 Protein in Patients with Sjogren Syndrome: Determination of the Plasma Level and Expression in the Labial Salivary Gland.<h4>Aims</h4>Growth arrest-specific protein 6 (Gas6) is a vitamin K-dependent protein expressed by endothelial cells and leukocytes that are involved in cell survival, migration, and proliferation in response to inflammatory processes. The aim of this study was to assess the implications of Gas6 in Sjögren syndrome (SS) and its expression in the labial salivary gland.<h4>Methods and results</h4>A total of 254 adults, including 159 with primary Sjögren syndrome (pSS), 34 with secondary Sjögren syndrome (sSS), and 61 normal controls, were recruited. Plasma Gas6 concentrations were determined, and Gas6 expressions in labial salivary gland (LSG) tissues from controls and pSS and sSS patients were also evaluated. Plasma Gas6 concentrations were significantly lower among patients with pSS than n2015-01-01T00:00:00Z20152025-04-04T10:50:41.124Z2019-03-26T23:27:41ZS-EPMC45968822644526610.1371/journal.pone.0139955