biostudies-literatureDavies NMCancer Research UKMedical Research CouncilNational Institute for Health Research (NIHR)NCI NIH HHSCIHR1603-16https://www.ebi.ac.uk/biostudies/studies/S-EPMC4596899biostudies-literatureUnknown26(11)<h4>Background</h4>Epidemiological studies suggest a potential role for obesity and determinants of adult stature in prostate cancer risk and mortality, but the relationships described in the literature are complex. To address uncertainty over the causal nature of previous observational findings, we investigated associations of height- and adiposity-related genetic variants with prostate cancer risk and mortality.<h4>Methods</h4>We conducted a case-control study based on 20,848 prostate cancers and 20,214 controls of European ancestry from 22 studies in the PRACTICAL consortium. We constructed genetic risk scores that summed each man's number of height and BMI increasing alleles across multiple single nucleotide polymorphisms robustly associated with each phenotype from published genome-wiCancer causes & control : CCCThe effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium.PMC4596899C18281/A19169C5047/A1069213065U19 CA148537C12292/A11174C1287/A10118C1281/A1201416491R01 CA128978MC_UU_12013/1A19169C16913/A6135G0500966/75466NIHR-RP-R3-12-013150071 U19 CA 148537-0117528U19 CA1480651U19 CA148065141361U19 CA148537G1000143C5047/A335416563G0500966C1287/A 10710C5047/A7357NF-SI-0512-10114MC_UU_12013/9MC_UU_12013/819170G0600705C5047/A8384R01 CA092447P30 CA015083G04015271U19 CA148112U19 CA148112CA128978C5047/A15007Southey MCSpurdle AThibodeau SMaia SPashayan NLane ALivni NEaston DMitev VIversen PKerr KHeathcote PZheng WKluzniak WStanford JLFisher CNeal DCook MKlarskov PKey TJAl Olama AAHazel SPharoah PBrenner HTravis RCBlot WJHenrique RMarsden GKibel ASPopov EMalone GDadaev TGeorge ASantos JAdolfson JKhaw KTSignorello LBCannon-Albright LKarlsson AWokozorczyk DMoya LVogel WHolly JTymrakiewicz MCavalli- Bjoerkman CTurner MSaunders EJKierzek ALubiski JJeronimo CSchleutker JChristova SCox ALim HYPaulo PRoder AMcDonnell SKEckert AStattin PWood GRincon MPRACTICAL consortiumLewis SJHenderson BEBatra JRiska SHerkommer KYeadon THamdy FCCybulski CRadlein SAuvinen APinto PEeles RMitkova AClements JAGuy MSaunders PTeixeira MRTaari KTammela TLLophatananon ADavis MWang LTillmans LWu HMichael ALuedeke MSchumacher FNordestgaard BGZachariah BButterbach KGustafsson SWiklund FMaeaettaenen LHamdy FBenlloch SKote-Jarai ZVlahova APark HDonovan JLPark JGaunt TRStegmaier CKemp JPSchaid DJGovindasami KJohansson JEDikov TWilkinson RHolleczek BNielsen SFWahlfors TKachakova DPow-Sang JHaley JMartin RMKujala PSchnoeller TMurtola TJugurnauth-Little SGiles GGSrinivasan SMuir KHaiman CAHopper JSellers TPedersen JBroms MLeongamornlert DSlavov CPandha HMorgan AGronberg HSawyer EJDavies NMFitzgerald LMCollins ABrown PSmith GDWallinder HMaier CKaneva RAly MLathrop MfalseThe effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium.<h4>Background</h4>Epidemiological studies suggest a potential role for obesity and determinants of adult stature in prostate cancer risk and mortality, but the relationships described in the literature are complex. To address uncertainty over the causal nature of previous observational findings, we investigated associations of height- and adiposity-related genetic variants with prostate cancer risk and mortality.<h4>Methods</h4>We conducted a case-control study based on 20,848 prostate cancers and 20,214 controls of European ancestry from 22 studies in the PRACTICAL consortium. We constructed genetic risk scores that summed each man's number of height and BMI increasing alleles across multiple single nucleotide polymorphisms robustly associated with each phenotype from published genome-wi2015-01-01T00:00:00Z2015 Nov2026-05-02T21:59:24.225Z2019-03-27T01:59:40ZS-EPMC45968992638708710.1007/s10552-015-0654-9