biostudies-literatureSeaberg ECNational Institute of Allergy and Infectious DiseasesNCATS NIH HHSNIDA NIH HHSNIAID NIH HHSNational Institutes of Health (NIH)NIMH NIH HHSNational Cancer InstituteNational Center for Advancing Translational ScienceNational Institute of Mental HealthNIHNational Institute on Drug Abuse1381-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC4599393biostudies-literatureUnknown61(9)<h4>Background</h4>The probability of spontaneous hepatitis C virus (HCV) clearance ranges from 11% to 49%. Our previous cross-sectional study suggests that mode of acquisition explains some of this heterogeneity. We performed this prospective study to determine factors associated with spontaneous HCV clearance among men who have sex with men (MSM).<h4>Methods</h4>A mixture-cure model was used to evaluate the probability of spontaneous HCV clearance among 101 MSM in the Multicenter AIDS Cohort Study with acute HCV infection between 1984 and 2012.<h4>Results</h4>Spontaneous HCV clearance occurred in 46% of MSM (49% in non-injection drug users [IDUs] and 23% in IDUs). In the multivariable analysis, age <30 years (clearance ratio [CR] = 2.43; 95% confidence interval [CI], 1.53-3.87) and beingClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaSpontaneous Clearance of the Hepatitis C Virus Among Men Who Have Sex With Men.PMC4599393U01-AI35039, U01-AI35040, U01-AI35041, U01-AI35042, UM1-AI35043, and DA013324UL1-TR000424 and UL1-TR001079U01-AI35039UL1 TR001079UL1 TR000424UM1 AI035043U01 AI035039UL1-TR000424UL1-TR001079U01 AI035041R01 DA013324U01 AI035040U01 AI035043UM1-AI35043U01 AI035042DA013324U01-AI35040U01-AI35042P30 MH058107U01-AI35041Thio CLDetels RYoung SSeaberg ECMargolick JBJacobson LPWitt MDRinaldo CRPhair JPfalseSpontaneous Clearance of the Hepatitis C Virus Among Men Who Have Sex With Men.<h4>Background</h4>The probability of spontaneous hepatitis C virus (HCV) clearance ranges from 11% to 49%. Our previous cross-sectional study suggests that mode of acquisition explains some of this heterogeneity. We performed this prospective study to determine factors associated with spontaneous HCV clearance among men who have sex with men (MSM).<h4>Methods</h4>A mixture-cure model was used to evaluate the probability of spontaneous HCV clearance among 101 MSM in the Multicenter AIDS Cohort Study with acute HCV infection between 1984 and 2012.<h4>Results</h4>Spontaneous HCV clearance occurred in 46% of MSM (49% in non-injection drug users [IDUs] and 23% in IDUs). In the multivariable analysis, age <30 years (clearance ratio [CR] = 2.43; 95% confidence interval [CI], 1.53-3.87) and being2015-01-01T00:00:00Z2015 Nov2025-05-18T11:19:43.007Z2025-05-18T11:19:43.007ZS-EPMC45993932617552110.1093/cid/civ562