{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["232(21-22)"],"submitter":["Loomis S"],"pubmed_abstract":["While treatment options are available, excessive daytime sleepiness (EDS) remains a significant unmet medical need for many patients. Relatively little rodent behavioural pharmacology has been conducted in this context to assess potential pro-vigilant compounds for their ability to restore functional capacity following experimentally induced sleep loss. Male Wistar rats were prepared for electroencephalographic (EEG) recording and subject to 11 h of sleep restriction using a biofeedback-induced cage rotation protocol. A simple response latency task (SRLT) was used to behaviourally index sleep restriction and the effects of pro-vigilant compounds: modafinil, D-amphetamine, caffeine, and the mGlu5-positive allosteric modulator LSN2814617. Sleep restriction resulted in a consistent, quantifie"],"journal":["Psychopharmacology"],"pagination":["3977-89"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4600478"],"repository":["biostudies-literature"],"pubmed_title":["Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617."],"pmcid":["PMC4600478"],"pubmed_authors":["Tricklebank M","Kellett DO","Loomis S","Baxter C","Gilmour G","McCarthy A","Edgar DM"],"additional_accession":[]},"is_claimable":false,"name":"Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617.","description":"While treatment options are available, excessive daytime sleepiness (EDS) remains a significant unmet medical need for many patients. Relatively little rodent behavioural pharmacology has been conducted in this context to assess potential pro-vigilant compounds for their ability to restore functional capacity following experimentally induced sleep loss. Male Wistar rats were prepared for electroencephalographic (EEG) recording and subject to 11 h of sleep restriction using a biofeedback-induced cage rotation protocol. A simple response latency task (SRLT) was used to behaviourally index sleep restriction and the effects of pro-vigilant compounds: modafinil, D-amphetamine, caffeine, and the mGlu5-positive allosteric modulator LSN2814617. Sleep restriction resulted in a consistent, quantifie","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Nov","modification":"2025-06-01T12:02:19.29Z","creation":"2025-06-01T12:02:19.29Z"},"accession":"S-EPMC4600478","cross_references":{"pubmed":["25902875"],"doi":["10.1007/s00213-015-3936-8"]}}