biostudies-literatureUnknown232(21-22)Loomis SWhile treatment options are available, excessive daytime sleepiness (EDS) remains a significant unmet medical need for many patients. Relatively little rodent behavioural pharmacology has been conducted in this context to assess potential pro-vigilant compounds for their ability to restore functional capacity following experimentally induced sleep loss. Male Wistar rats were prepared for electroencephalographic (EEG) recording and subject to 11 h of sleep restriction using a biofeedback-induced cage rotation protocol. A simple response latency task (SRLT) was used to behaviourally index sleep restriction and the effects of pro-vigilant compounds: modafinil, D-amphetamine, caffeine, and the mGlu5-positive allosteric modulator LSN2814617. Sleep restriction resulted in a consistent, quantifiePsychopharmacology3977-89https://www.ebi.ac.uk/biostudies/studies/S-EPMC4600478biostudies-literatureDistinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617.PMC4600478Tricklebank MKellett DOLoomis SBaxter CGilmour GMcCarthy AEdgar DMfalseDistinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617.While treatment options are available, excessive daytime sleepiness (EDS) remains a significant unmet medical need for many patients. Relatively little rodent behavioural pharmacology has been conducted in this context to assess potential pro-vigilant compounds for their ability to restore functional capacity following experimentally induced sleep loss. Male Wistar rats were prepared for electroencephalographic (EEG) recording and subject to 11 h of sleep restriction using a biofeedback-induced cage rotation protocol. A simple response latency task (SRLT) was used to behaviourally index sleep restriction and the effects of pro-vigilant compounds: modafinil, D-amphetamine, caffeine, and the mGlu5-positive allosteric modulator LSN2814617. Sleep restriction resulted in a consistent, quantifie2015-01-01T00:00:00Z2015 Nov2025-06-01T12:02:19.29Z2025-06-01T12:02:19.29ZS-EPMC46004782590287510.1007/s00213-015-3936-8