biostudies-literatureNagaraja VNIAMS NIH HHS1944-53https://www.ebi.ac.uk/biostudies/studies/S-EPMC4603276biostudies-literatureUnknown54(11)SSc is a multiorgan disease with significant morbidity that is associated with poor health-related quality of life. Treatment of this condition is often organ based and non-curative. However, there are newer, potentially disease-modifying therapies available to treat certain aspects of the disease. This review focuses on old and new therapies in the management of SSc in clinical practice.Rheumatology (Oxford, England)Old medications and new targeted therapies in systemic sclerosis.PMC4603276K24 AR063120Denton CPKhanna DNagaraja VfalseOld medications and new targeted therapies in systemic sclerosis.SSc is a multiorgan disease with significant morbidity that is associated with poor health-related quality of life. Treatment of this condition is often organ based and non-curative. However, there are newer, potentially disease-modifying therapies available to treat certain aspects of the disease. This review focuses on old and new therapies in the management of SSc in clinical practice.2015-01-01T00:00:00Z2015 Nov2021-02-20T03:33:31Z2019-03-27T01:59:58ZS-EPMC46032762506501310.1093/rheumatology/keu285